Experimental study comparing the effects of early and physiological estrogen deficiency on cardiovascular control - the role of hormone replacement and aerobic physical training

• Grant number: 08/10929-9
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2009
• End date: June 30, 2011
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Hugo Celso Dutra de Souza
• Grantee: Hugo Celso Dutra de Souza
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The objective of the present study is to analyse and to compare the effects of early and physiological estrogen deficiency as well as the effect of hormone replacement and aerobic physical training on the cardiovascular control in these two situations. A total of 120 Wistar female rats will be distributed into two major groups: a group of young female rats (10 weeks old) and another group of old ones (70 weeks old). Each group will be further divided into three subgroups: group of sham rats (vehicle); group of ovariectomized rats without hormone reposition (vehicle); and group of ovariectomized rats submitted to estrogen replacement. Half of the animals in each subgroup will be submitted to aerobic physical training through swimming. All the animals will be also submitted to experimental procedures for recording arterial pressure (AP) and heat rate (HR) so that the cardiovascular autonomic function can be assessed. Such an assessment will be carried out by means of different approaches: study of tonic autonomic control of HR by administering methylatropine and atenolol, analysis of HR and AP variability, assessment of baroreflex sensitivity, dosage of circulating catecholamines and expression of beta-adrenergic receptors. Moreover, all the animals will be submitted to functional study of the vascular reactivity in the coronary bed. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TEZINI, GEISA C. S. V.; BECARI, CHRISTIANE; ZANOTTO, CAMILA Z.; SALGADO, MARIA CRISTINA O.; TOSTES PASSAGLIA, RITA DE CASSIA A.; SOUZA, HUGO C. D.. Ageing is the main determinant of haemodynamics and autonomic cardiac changes observed in post-menopausal female rats. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 174, n. 1-2, p. 36-41, MAR 2013. (08/10929-9)

FELIX, ANA CAROLINA S.; DUTRA, SABRINA G. V.; TEZINI, GEISA C. S. V.; SIMOES, MARCUS VINICIUS; DUTRA DE SOUZA, HUGO CELSO. Aerobic physical training increases contractile response and reduces cardiac fibrosis in rats subjected to early ovarian hormone deprivation. Journal of Applied Physiology, v. 118, n. 10, p. 1276-1285, MAY 15 2015. (08/10929-9, 14/01937-9)

TEZINI, GEISA C. S. V.; DIAS, DANIEL P. M.; SOUZA, HUGO C. D.. Aerobic physical training has little effect on cardiovascular autonomic control in aging rats subjected to early menopause. Experimental Gerontology, v. 48, n. 2, p. 147-153, FEB 2013. (08/10929-9)