Effect of protein and phosphorus overload on the progression of kidney disease: evaluation of the pathophysiological mechanisms

• Grant number: 10/05409-6
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2010
• End date: November 30, 2012
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Rosa Maria Affonso Moysés
• Grantee: Rosa Maria Affonso Moysés
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Clarice Kazue Fujihara ; Luciene Machado dos Reis ; Roberto Zatz ; Vanda Jorgetti

Abstract

Chronic kidney disease (CKD) is a public health issue that mobilizes the global medical community about the prevention and retardation of its evolution. The role of protein overload in renal function arouses the interest of the nephrology community for decades, due to its effect of slowing the progression of CKD. It has never been studied to separate the effect of protein overload of the effect of overload of phosphorus, namely to make restriction of protein without performing restriction of phosphorus. This project aims to evaluate the effect of isolated overload of phosphorus and protein in the progression of renal disease in uremic rats. Munich Wistar rats will be submitted to 5/6 nephrectomy (n=40) or to Sham-nephrectomy (n=10). Animals will be divided into 5 groups according to the concentration of protein and phosphorus in the diet. After 8 weeks of exposure to diet, an evaluation of renal physiology with functional study, evaluation of apoptosis of renal parenchyma, histological and immunohistochemical study will be performed. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DUAYER, IRENE FARIA; DUQUE, EDUARDO JORGE; FUJIHARA, CLARICE KAZUE; DE OLIVEIRA, IVONE BRAGA; DOS REIS, LUCIENE MACHADO; MACHADO, FLAVIA GOMES; GRACIOLLI, FABIANA GIORGETTI; JORGETTI, VANDA; ZATZ, ROBERTO; ELIAS, ROSILENE MOTTA; et al. The Protein-Independent Role of Phosphate in the Progression of Chronic Kidney Disease. TOXINS, v. 13, n. 7, JUL 2021. (10/05409-6)