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Signaling and differentiation of the organ of Corti cells: perspectives for treating hearing loss

Grant number: 09/09473-3
Support type:Regular Research Grants
Duration: January 01, 2010 - December 31, 2011
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Ricardo Ferreira Bento
Grantee:Ricardo Ferreira Bento
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Most forms of congenital and acquired hearing loss arise from damage to cochlear hair cells or their associated neurons. In mammals, the replacement of lost hair cells does not occur spontaneously since these cells are terminally-differentiated. Clinically, the loss of hair cells can be treated by electric stimulation of auditive nerve by cochlear implants. However, other therapeutic approaches for hearing loss restoration have been investigated and include cellular replacement by stem cell therapy and induction of intrinsic tissue regeneration by gene therapy. This study aims to create and develop a research line on hearing loss regeneration through the following main goals: (i) to standardize procedures to obtain and to transplant progenitor cells into the organ of Corti (ii) to standardize procedures of genetic and phenotypic interference on organ of Corti progenitor cells and support cells. The achievement of these goals will create the experimental conditions for the further development of gene and cell therapy strategies on hearing loss. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LUIZ GUSTAVO DUFNER-ALMEIDA; DAYANE BERNARDINO DA CRUZ; REGINA CÉLIA MINGRONI NETTO; ANA CARLA BATISSOCO; JEANNE OITICICA; RODRIGO SALAZAR-SILVA. Stem-cell therapy for hearing loss: are we there yet?. Brazilian Journal of Otorhinolaryngology, v. 85, n. 4, p. 520-529, Ago. 2019.
BARBOZA, JR., L. C. M.; LEZIROVITZ, K.; ZANATTA, D. B.; STRAUSS, B. E.; MINGRONI-NETTO, R. C.; OITICICA, J.; HADDAD, L. A.; BENTO, R. F. Transplantation and survival of mouse inner ear progenitor/stem cells in the organ of Corti after cochleostomy of hearing-impaired guinea pigs: preliminary results. Brazilian Journal of Medical and Biological Research, v. 49, n. 4 2016. Web of Science Citations: 2.

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