Remote ischemic preconditioning in patients with intermittent claudication of the lower limbs

• Grant number: 08/03203-1
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2008
• End date: June 30, 2009
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Nelson Wolosker
• Grantee: Nelson Wolosker
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo

Abstract

Intermittent claudication is one of the most frequent manifestations of atherosclerotic disease. The major treatment modality for patients with claudication is supervised exercise, which promotes intracellular biochemical adaptations that improve the walking ability. However, those mechanisms are still not completely known and one of the hypotheses made was that ischemia/reperfusion outbreaks provoked by the exercise would stimulate the adaptations described above. Recent studies about the ischemia/reperfusion phenomenon permitted a better understanding of the ischemic pre-conditioning concept. It concerns about an increasing tolerance to ischemia caused by previous shorter and milder ischemia periods, mediated by a large amount of intra and extra cellular substances. There are evidences that this improvement in the muscle tolerance to ischemia could be reproduced by periods of ischemia/reperfusion of distinct and distant organs, a phenomenon called remote ischemic pre-conditioning. Therefore, it was imagined that was possible to provoke remote ischemic pre-conditioning in patients with intermittent claudication of the lower limbs. In order to test this hypothesis, light intermittent ischemia will be induced in the upper limb of the patient and the influence of this procedure on the tolerance to functional ischemia of the lower limbs will be analyzed. This tolerance to ischemia in the lower limbs will be measured by the working capacity of this musculature, represented by the walking distance on the walk test. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GLAUCO FERNANDES SAES; ANTONIO EDUARDO ZERATI; NELSON WOLOSKER; LUCIANA RAGAZZO; RUBEN MIGUEL AYZIN ROSOKY; RAPHAEL MENDES RITTI-DIAS; GABRIEL GRIZZO CUCATO; MARCELO CHEHUEN; BRENO QUINTELLA FARAH; PEDRO PUECH-LEÃO. Remote ischemic preconditioning in patients with intermittent claudication. Clinics, v. 68, n. 4, p. 495-499, 2013-04-00. (08/03203-1)