Evaluation of actinically induced labial lesions using relfectance confocal microscopy

• Grant number: 09/52915-7
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2010
• End date: January 31, 2012
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Silvia Vanessa Lourenço
• Grantee: Silvia Vanessa Lourenço
• Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Actinic cheilitis is considered as the incipient and superficial presentation of actinicaly induced squamous cell carcinoma of the lip vermillion. In a recent study, we have shown that cases of actinic cheilitis with difuse clinical aspects may bear important histological alterations. In these cases, clinical evaluation is difficult and non-invasive methods to exmine the lip vermillion are required (NICO et al, 2007). Reflectance confocal microscopy (CRM) has been considered useful in the evaluation of actinically induced cutaneous lesions, with high sensitivity and sensibility in the diagnosis of these lesions. Its use in the evaluation of actinic cheilitis has not been studied. Therefore we propose an investigation of the aspects of actinic cheilitis using CRM. These aspects will be compared with the histopathological alterations of the biospied lesions in each case. The study aims to establish morphological criteria using the images generated by the RCM and to analyse if RCM can be used as an adjunct tool to clinical diagnosis and monitoring of actinic cheilitis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LOURENCO, SILVIA V.; KOS, ELIANA; NUNES, THAIS BORGUEZAN; BOLOGNA, SHEYLA B.; SANGUEZA, MARTIN; NICO, MARCELLO M. S.. In Vivo Reflectance Confocal Microscopy Evaluation of Cheilitis Glandularis: A Report of 5 Cases. AMERICAN JOURNAL OF DERMATOPATHOLOGY, v. 37, n. 3, p. 197-202, MAR 2015. (09/52915-7)

ALESSI, S. S.; NICO, M. M. S.; FERNANDES, J. D.; LOURENCO, S. V.. Reflectance confocal microscopy as a new tool in the in vivo evaluation of desquamative gingivitis: patterns in mucous membrane pemphigoid, pemphigus vulgaris and oral lichen planus. British Journal of Dermatology, v. 168, n. 2, p. 257-264, FEB 2013. (09/52915-7)

FERREIRA, PAULA SILVA; ROCHA, LILIAN; CARNEIRO BEZERRA, ANA PATRICIA; SIMONSEN NICO, MARCELLO MENTA; LOURENCO, SILVIA VANESSA. Reflectance confocal microscopy (RCM)-based criteria for progression of lower-lip squamous cell carcinoma: A prospective study. Oral Oncology, v. 125, FEB 2022. (09/52915-7)