The climacteric syndrome on liver transplant recipients

• Grant number: 08/09726-6
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2009
• End date: March 31, 2011
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Aarao Mendes Pinto Neto
• Grantee: Aarao Mendes Pinto Neto
• Host Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The survival rates of liver transplant recipients have been increasing in the last years. In consequence there is an increase in the number of women with liver transplant in the climacteric phase.Objectives: To evaluate the climacteric symptoms, the hormonal and metabolic profiles, the ultrasonographic ovarian aspect, the bonemineral density and the quality of life of women with liver transplant.Methods: a cross-sectional study will be carried out with approximately thirty women with liver transplant in follow-up on the Unity of Liver Transplantation of the State University of Campinas - Unicamp, compared with women without liver transplant in follow-up on the Menopause Clinic in the Women's Health Center of the State University of Campinas - Unicamp. The climacteric symptoms will be evaluated with the Menopause Rating Scale (MRS). The evaluation of the genital trophysm will be carried out with hormonal cytology of the vaginal secretions and with the Vaginal Health Score Index (VHIS). Hormonal and metabolic dosages, bone densitometry and transvaginal ultrasound will also be carried out. The quality of life will be evaluated with the World Health Organization Quality of Life Questionnaire (WHOQOL-bref). The subjects selection and gynecological exams will be carried out at the Menopause Clinic in the Women's Health Center of the State University of Campinas - Unicamp.Statistical analysis: The Student's T test will be used to compare among the groups the climacteric symptoms, the quality of life, the vaginal health score index, the hormonal and metabolic profiles, the ovarian volume and the antral follicle number when the variables present normal distribution. If the normality supposition is not verified, then the test of Mann-Whitney will be used. The association between bone mineral density and vaginal hormonal cytology among the groups will be verified with the Qui-square test. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LUIZ FRANCISCO BACCARO; ILKA DE FÁTIMA BOIN; LÚCIA COSTA-PAIVA; ALINE GARCIA LEAL; CELSO DARIO RAMOS; AARÃO MENDES PINTO-NETO. O transplante hepático está associado a menor massa óssea em mulheres climatéricas?. Revista Brasileira de Ginecologia e Obstetrícia, v. 34, n. 7, p. 335-342, 2012-07-00. (08/09726-6)

LUIZ FRANCISCO BACCARO; ILKA DE FÁTIMA BOIN; LÚCIA COSTA-PAIVA; AARÃO MENDES PINTO-NETO. Qualidade de vida e sintomas da menopausa em mulheres transplantadas hepáticas. Revista Brasileira de Ginecologia e Obstetrícia, v. 35, n. 3, p. 103-110, 2013-03-00. (08/09726-6)