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Morphofuncitonal changes in Wistar rat prostate: fetal programming by protein restriction in utero and chronic exposure to cadmium and caffeine during puberty


This Project is a consolidation of three subprojects that already are supported by FAPESP as one Post-doc fellowship and two doctoral fellowships. The first minor Project has the main objective to investigate the effects of fetal programming by protein restriction in útero on adult rat prostate morphophysiology. It is widely know that adverse gestational conditions can promote unreversible morphofunctional changes/adaptations in the feto, phenomenon denominated fetal programming. The protein restriction in utero is the most extensible studied model of fetal programming and, in Brazil; the matern undernutriction is an extremaly relevant issue. In the fetal programming by in utero protein restriction, the fetos are exposed to higher matern concentration of glucocorticoids, estrogen and androgens. Considering the participation of these steroids hormones in the development and mantainance of male reproductive system, especially on prostate, we believe to be extremally relevant to investigate the effects of this kind of fetal programming on prostate morphophysiology. The second minor project has the objective to evaluate if this kind of fetal programming causes a simillar effects from the classic estrogenic imprinting of the prostate, in which prostate cells remain prediposed to develop proliferative lesions when exposed to estrogen again in adult life. And in the third minor project we will aprofundate the studies about the effects of a chronic exposure to cadmium and/or caffeine on the pubertal prostate growth, with special attention to the extracellular matrix and ultrastructure. For this, the ventral and dorsolateral prostatic lobes will be submitted to morphological, morphometric, cytochemical, immunocytochemical, utrastructural and biochemical analyze. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LACORTE, LIVIA M.; RINALDI, JAQUELINE C.; JUSTULIN, JR., LUIS A.; DELELLA, FLAVIA K.; MOROZ, ANDREI; FELISBINO, SERGIO L. Cadmium exposure inhibits MMP2 and MMP9 activities in the prostate and testis. Biochemical and Biophysical Research Communications, v. 457, n. 4, p. 538-541, FEB 20 2015. Web of Science Citations: 12.
RINALDI, JAQUELINE C.; JUSTULIN, JR., LUIS A.; LACORTE, LIVIA M.; SAROBO, CAROLINA; BOER, PATRICIA A.; SCARANO, WELLERSON R.; FELISBINO, SERGIO L. Implications of intrauterine protein malnutrition on prostate growth, maturation and aging. Life Sciences, v. 92, n. 13, p. 763-774, APR 19 2013. Web of Science Citations: 16.
LACORTE, LIVIA M.; SEIVA, FABIO R. F.; RINALDI, JAQUELINE C.; DELELLA, FLAVIA K.; MOROZ, ANDREI; SAROBO, CAROLINA; GODINHO, ANTONIO F.; FAVARO, WAGNER J.; FERNANDES, ANA A. H.; FELISBINO, SERGIO L. Caffeine reduces cadmium accumulation in the organism and enhances the levels of antioxidant protein expression in the epididymis. REPRODUCTIVE TOXICOLOGY, v. 35, p. 137-143, JAN 2013. Web of Science Citations: 19.
SAROBO, CAROLINA; LACORTE, LIVIA M.; MARTINS, MARCELA; RINALDI, JAQUELINE C.; MOROZ, ANDREI; SCARANO, WELLERSON R.; DELELLA, FLAVIA K.; FELISBINO, SERGIO L. Chronic caffeine intake increases androgenic stimuli, epithelial cell proliferation and hyperplasia in rat ventral prostate. International Journal of Experimental Pathology, v. 93, n. 6, p. 429-437, DEC 2012. Web of Science Citations: 14.

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