Use of antigenemia technique for diagnosis and monitoring of infections caused by cytomegalovirus (CMV), herpesvirus 6 and 7 (HHV-6 and HHV-7) in transplant patients hematopoietic stem cell

• Grant number: 09/17830-0
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2010
• End date: April 30, 2013
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Sandra Helena Alves Bonon
• Grantee: Sandra Helena Alves Bonon
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Sandra Cecília Botelho Costa

Abstract

The herpesviruses are major causes of complications after transplantation because of their latent nature and reinfection due to immunosuppressive drugs, leading the individual susceptibility to infection and disease. The use of diagnostic techniques such infections are becoming increasingly necessary, including directing the treatment and during periods where the infection is active viral replication occurs. Diagnostic methods such as antigenemia are excellent for use in diagnosis and monitoring of these patients, allowing early diagnosis and semi-quantitative, offering patients a more appropriate early treatment with antivirals or reduction of immunosuppression, infection control, not to run the illness or even death. (AU)