Interaction of the intestinal microbiota and absorptive digestive function with social environment and nutritional condition: intestinal disorders as arguments for reducing inequities

• Grant number: 09/18458-8
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2010
• End date: July 31, 2012
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Mauro Batista de Morais
• Grantee: Mauro Batista de Morais
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Over the last few years the increase in interest concerning the role of prebiotics and probiotics in the promotion of health and in the working of the intestine has determined an increase in scientific production within this area of knowledge. Between 2006 and 2008 a project involving a partnership between the Federal University of São Paulo (UNIFESP) and the University Center of the Teaching Institute Foundation of Osasco (UNIFIEO) was developed in which two groups of children were compared: 1. those living in a shantytown; 2. pupils at a private school. As a result it was verified that there was a higher number of children with bacterial overgrowth and with colonic production of methane in the shantytown group. Bifid bacterial and lactobacillus cultures revealed a lower number of colony forming units in the feces of the shantytown children when compared to those of the private school pupils. In accordance with the hydrogen test on expired air, the administration of anti-microbes was efficient in the treatment of bacterial overgrowth. In the current project, within which two doctorate and one master's theses will be developed, and in which children pertaining to two socio-economic groups will be studies, the fundamental objectives are: 1. to evaluate the properties of the intestinal microbiota in children with and without overgrowth in the small intestine, researched via the hydrogen test on expired air; 2. To study the differences in the colonic microbiota of children, with atopy, malnutrition and with obesity, pertaining to two socio-economic groups; 3. To verify the relationship between the methane production of expired air and the participation of Methanobrevibacter smithii in the microbiota. In this project the same research instruments used during 2006/2008, as well as the addition of a real time PCR, will be used in order to analyze the qualitative and quantitative properties of the colonic microbiota. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE ARAUJO FILHO, HUMBERTO BEZERRA; CARMO-RODRIGUES, MIRIAN SILVA; MELLO, CAROLINA SANTOS; FONSECA LAHOZ MELLI, LIGIA CRISTINA; TAHAN, SORAIA; CAMPOS PIGNATARI, ANTONIO CARLOS; DE MORAIS, MAURO BATISTA. Children Living near a Sanitary Landfill Have Increased Breath Methane and Methanobrevibacter smithii in Their Intestinal Microbiota. ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL, 2014. (09/18458-8)

FONSECA LAHOZ MELLI, LIGIA CRISTINA; DO CARMO-RODRIGUES, MIRIAN SILVA; ARAUJO-FILHO, HUMBERTO BEZERRA; MELLO, CAROLINA SANTOS; TAHAN, SORAIA; CAMPOS PIGNATARI, ANTONIO CARLOS; SOLE, DIRCEU; DE MORAIS, MAURO BATISTA. Gut microbiota of children with atopic dermatitis: Controlled study in the metropolitan region of Sao Paulo, Brazil. ALLERGOLOGIA ET IMMUNOPATHOLOGIA, v. 48, n. 2, p. 107-115, MAR-APR 2020. (09/18458-8)

DE ARAUJO FILHO, HUMBERTO BEZERRA; CARMO-RODRIGUES, MIRIAN SILVA; MELLO, CAROLINA SANTOS; FONSECA LAHOZ MELLI, LIGIA CRISTINA; TAHAN, SORAIA; CAMPOS PIGNATARI, ANTONIO CARLOS; DE MORAIS, MAURO BATISTA. Children Living near a Sanitary Landfill Have Increased Breath Methane and Methanobrevibacter smithii in Their Intestinal Microbiota. ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL, v. 2014, p. 6-pg., 2014-01-01. (09/18458-8)