Effect of GCSF on facial nerve regeneration of primates

• Grant number: 09/52805-7
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2009
• End date: October 31, 2011
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Oswaldo Laércio Mendonça Cruz
• Grantee: Oswaldo Laércio Mendonça Cruz
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The treatment of peripheral facial paralysis presents still modest results in medical practice and the study of neurotrophic substances is an interesting possibility for improving this framework. The GCSF (granulocyte colony-stimulating factor or colony-stimulating factor 3) has been considered a major candidate as neurotrophic factors, due to its clinical safety has been established. Experimental evidence of the role of GSCF like a neurotrophic factors are already available in experimental models of brain injury, injury of spinal cord and peripheral nerve injury. In our project we propose test the influence of systemic administration of GCSF (20 g intraperitoneally for 5 days) after acute injury of the facial nerve (4 weeks of observation) in non-human primate model (Callitrix n=17). We will be considered behavior and histological evaluations for this. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NEIVA, FELIPE COSTA; BORIN, ANDREI; CININI, SIMONE; MELLO, LUIZ EUGENIO A. M.; CRUZ, OSWALDO LAERCIO M.; TESTA, JOSE RICARDO G.. Experimental model of facial paralysis by nerve compression in primates (Callithrix sp.): A new model of facial paralysis in small nonhuman primates. ACTA OTO-LARYNGOLOGICA, v. 132, n. 11, p. 1239-1242, NOV 2012. (09/52805-7)

BORIN, ANDREI; MELLO, LUIZ EUGENIO ARAUJO M.; NEIVA, FELIPE COSTA; GURGEL TESTA, JOSE RICARDO; MENDONCA CRUZ, OSWALDO LAERCIO. Experimental Video Analysis of Eye Blink Reflex in a Primate Model. OTOLOGY & NEUROTOLOGY, v. 33, n. 9, p. 1625-1629, DEC 2012. (09/52805-7)