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Effect of electrical stimulation of cranial tibial muscle after end to side neurorraphy on fibular nerve in rats

Grant number: 10/09866-2
Support type:Regular Research Grants
Duration: February 01, 2011 - January 31, 2013
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Fausto Viterbo de Oliveira Neto
Grantee:Fausto Viterbo de Oliveira Neto
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Assoc. researchers: Fábio Oliveira Maciel

Abstract

In treatment of peripheral nerve injuries by neurorrhaphy, has not yet get full motor recovery as well as it has been done to repair the injured nerve. For this reason many studies seek to propose techniques to improve the functionality of a reinnervated muscle such as the end-to-side neurorrhaphy without injury to the donor nerve. This technique brought a great contribution, because any nerve can be used as donor nerve without damage to it or to structures innervated by it. This finding aroused great interest in scientific community, demonstrating successful results in the treatment of cases such as facial palsy, brachial plexus avulsion and numerous other possibilities with peripheral nerve injury. After a neurorrhaphy the time needed for regeneration, determine muscle atrophy and electrical stimulation could prevent this factor. This research aims to study the efficiency of electrical stimulation on recovery of the cranial tibial muscle after section and end-to-side neurorrhaphy of the distal stump of the peroneal nerve on the side of the tibial nerve. Will be used 60 Wistar rats, male, weighing approximately 200 g. The animals will be randomly divided into four experimental groups. Group 1, normal control group. Group 2, control group of denervation. Group 3, end-to-side neurorrhaphy of the distal stump of the peroneal nerve on the side of the tibial nerve. Group 4, end-to-side neurorrhaphy of the distal stump of the peroneal nerve on the side of the tibial nerve plus electrical stimulation in the cranial tibial muscle as part of treatment. (AU)

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