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Uricostatic, uricosuric and antioxidant interventions in mice inoculated with Crotalus durissus terrificus venom

Grant number: 09/00509-5
Support Opportunities:Regular Research Grants
Duration: April 01, 2009 - March 31, 2011
Field of knowledge:Biological Sciences - Physiology - Compared Physiology
Principal Investigator:Paulo Flávio Silveira
Grantee:Paulo Flávio Silveira
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


Envenoming by Crotalus snakes is an important medical problem, because is responsible for high incidence of morbidity and mortality. One of the most serious complications in accidents evoked by this snake genus is acute renal failure (ARF). Recently, our group demonstrated that 80% LD50 of the venom of the rattlesnake Crotalus durissus terrificus, one of the main species responsible for snakebite accidents in Brazil, caused 100% incidence of hyperuricemia and urinary hypoosmolality, fact which was suggestive that both alterations are early signs of myotoxicity and indirect effects of this venom (vCdt) (Yamasaki et al, 2008). The oxidative stress, evaluated by GSH and GSSG contents, was also evidenced as part of nephrotoxic effect of vCdt. In this sense, drugs that reduce uric acid and oxidative stress could mitigate or prevent the ARF caused by vCdt. The aim of the present project is to evaluate this possibility through measurements of lethality and changes on parameters of renal function and oxidative stress after administration of C. d. terrificus venom (80% da DL50) in mice treated with representative drugs of these classes. The results of this study may help the understanding about mechanisms of ARF induced by vCdt and to point out potential agents that could complement the treatment of this envenomation. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FREZZATTI, RODRIGO; SILVEIRA, PAULO FLAVIO. Allopurinol Reduces the Lethality Associated with Acute Renal Failure Induced by Crotalus durissus terrificus Snake Venom: Comparison with Probenecid. PLoS Neglected Tropical Diseases, v. 5, n. 9, p. e1312, . (09/00509-5)

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