| Grant number: | 09/10759-9 |
| Support Opportunities: | Regular Research Grants |
| Start date: | October 01, 2009 |
| End date: | March 31, 2012 |
| Field of knowledge: | Biological Sciences - Immunology - Cellular Immunology |
| Principal Investigator: | Paulina Sannomiya |
| Grantee: | Paulina Sannomiya |
| Host Institution: | Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| City of the host institution: | São Paulo |
Abstract
Hemodynamic, neurohumoral, and immunological alterations may combine to deteriorate the intrinsic quality of the organ procurement and/or exacerbate ischemia/reperfusion injury during the ensuing cold preservation and transplantation. This study aims to investigate microcirculatory changes through the in vivo and in situ observation of the mesenteric microcirculation in a rat model of brain death and the effects of continuous thoracic epidural anesthesia (0.5% bupivacaine) on the development of the inflammatory process. The design includes the investigation of: (1) leukocyte-endothelial interactions in the mesenteric microcirculation by intra-vital microscopy; (2) expression of P-selectin and ICAM-1 on mesenteric microvessels by immunohistochemistry; (3) serum cytokines and corticosterone levels by ELISA; (4) hemodynamic parameters, blood gases and electrolytes, and blood leukocyte counts. (AU)
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