The organ transplantation has evolved as the treatment of choice for many patients with end-stage disease. However, clinical studies show differences in the prognosis of short and long-term transplants due to donor gender. Clinical and experimental evidence also highlight the impact of brain death on the viability of the organ to be transplanted and show the importance of the donor state in the final results of the transplant. Brain death triggers the immune system activation which is characterized by the expression of inflammatory mediators, including cytokines, chemokines and adhesion molecules, and inflammatory cell infiltration to the organs. Although there is evidence that the immune response (innate and adaptive) differs between men and women, sexual dimorphism does not receive deserved attention as a potential factor for the different immune responses observed between men and women. Sex hormones may exert modulatory role on the inflammatory response and contribute to the hemodynamic deterioration. Organic and immunological changes could favor the later appearance of the rejection phenomena in the recipient. Sex steroids can also exhibit direct effects on cells of the immune system. Preliminary results obtained with rats have indicated differences in cell mobilization after induction of brain death. From the idea that sexual dimorphism exists in the immune response to brain death and might be responsible for differences in the prognosis of organ transplants, in this study we aim to investigate the differences between the genders regarding the microcirculatory changes and the evolution of the inflammatory process in different organs in a model of brain death in rats. (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
BREITHAUPT-FALOPPA, ANA CRISTINA;
FERREIRA, SUELI G.;
KUDO, GUILHERME K.;
ARMSTRONG, JR., ROBERTO;
FERRAZ DA SILVA, LUIZ FERNANDO;
MOREIRA, LUIZ FELIPE P.
Sex-related differences in lung inflammation after brain death.
JOURNAL OF SURGICAL RESEARCH,
Web of Science Citations: 3.