Influence of exercise upon local mechanisms involved in the isolated rat vein responses to norepinephrine and angiotensin II

• Grant number: 09/09788-4
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2010
• End date: June 30, 2012
• Field of knowledge: Biological Sciences - Pharmacology - Cardiorenal Pharmacology
• Principal Investigator: Agnaldo Bruno Chies
• Grantee: Agnaldo Bruno Chies
• Host Institution: Faculdade de Medicina de Marília (FAMEMA). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). Marília , SP, Brazil

Abstract

Physical exercise evokes an extensive circulatory redistribution that involves changes of tonus in either arteries or veins. Indeed, the exercise possibly modifies the local mechanisms related to nitric oxide (NO), prostanoids and/or endothelin-1 that influence the effects of sympathetic agonists and angiotensin II (Ang II) in veins. This hypothesis was investigated in our preliminary study that aimed to determinate whether exercise modifies the effects of phenylephrine and Ang II in portal veins taken from trained rats. It was verified the exercise enhanced the rat portal vein responses to these agonists. It is also indirectly evidenced that such enhancement of response to phenylephrine and Ang II appears to involve an enhancement of vasocontractile influence of endothelin-1 that supplants the modulation exerted by nitric oxide (NO) and vasodilator prostanoids. Thus, the present project aims to expand this investigation, verifying the exercise effects upon the local expression of endothelin-1and/or receptors ETA/ETB as well as the actions of exogenous endothelin-1 in rat portal vein. Considering that the aforementioned study showed exercise-induced enhancement of phenylephrine and Ang II responses in portal vein but not in vena cava, it will be also investigated the influence of exercise upon other venous beds responses to these agonists. In this manner, such veins will be studied either by organ bath experiments or by quantitative real time RT-PCR. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHIES, AGNALDO BRUNO; ROSSIGNOLI, PATRICIA DE SOUZA; FERREIRA BAPTISTA, RAFAELA DE FATIMA; DE LABIO, ROGER WILLIAM; MARQUES PAYAO, SPENCER LUIZ. Exercise reduces angiotensin II responses in rat femoral veins. Peptides, v. 44, p. 47-54, JUN 2013. (09/09788-4)

CHIES, AGNALDO BRUNO; DE OLIVEIRA, PRISCILLA BIANCA; ROSSIGNOLI, PATRICIA DE SOUZA; FERREIRA BAPTISTA, RAFAELA DE FATIMA; DE LABIO, ROGER WILLIAM; MARQUES PAYAO, SPENCER LUIZ. Prostanoids counterbalance the synergism between endothelin-1 and angiotensin II in mesenteric veins of trained rats. Peptides, v. 88, p. 67-73, FEB 2017. (09/09788-4)

LUCAS FADEL CAMARGO; GUILHERME DONZALISKY PINHEIRO; PRISCILLA BIANCA DE OLIVEIRA; DANIELE MORAES LOSADA; EDUARDO FEDERIGHI BAISI CHAGAS; MÁRCIA APARECIDA SPERANÇA; AGNALDO BRUNO CHIES; MARIA ANGÉLICA SPADELLA; LUCIAMÁRE PERINETTI ALVES MARTINS. Influence of galantamine in the inflammatory process and tissular lesions caused by Trypanosoma cruzi QM2 strain. Revista da Sociedade Brasileira de Medicina Tropical, v. 54, 2021-11-12. (17/08606-6, 09/09788-4)