Influence of salt levels in renal profile and cardiovascular function in an experimental model of insulin resistance: role of renin-angiotensin system

• Grant number: 09/52556-7
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2009
• End date: November 30, 2011
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: vera de moura azevedo farah
• Grantee: vera de moura azevedo farah
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Presbiteriana Mackenzie (UPM). Instituto Presbiteriano Mackenzie. São Paulo , SP, Brazil

Abstract

The risk for the onset of cardiovascular disease increases progressively when the association in the same individual risk factors alone as insulin resistance, hyperinsulinemia, dyslipidemia and hypertension. In animals, administration of a rich diet in fructose or the addition of fructose in water, initiating a series of metabolic events resulting in hypertriglyceridemia, hypertension, insulin resistance and glucose intolerance. These metabolic and physiological changes are similar to those found in clinical characteristic of the human metabolic syndrome. There is a close relationship between the metabolism of glucose and renin angiotensin system (RAS). Different studies have shown that increased consumption of fructose promotes activation of the RAS that contributes to the increase in blood pressure observed in this model. Several studies suggest that the handling of sodium is involved in the pathogenesis of hypertension as well as changes in the homeostatic balance of the RAS. Furthermore, diabetic patients are often sensitive to diets rich in salt and its increase in the diet can predispose to renal complications and result in increases in blood pressure and risk of cardiovascular events. These data together suggest that the association of different cardiovascular risk factors, such as fructose and salt intake in the same individual, may enhance the changes in cardiovascular and renal function. Therefore, the purpose of this study is to investigate the association of two cardiovascular risk factors, salt and fructose overloading in hemodynamic and renal function in rats treated chronically from weaning until 8 weeks and the role of the RAS in cardiovascular and renal homeostasis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MORRIS, MARIANA; ARAUJO, IARA C.; POHLMAN, ROBERTA L.; MARQUES, MARIANA C.; RODWAN, NAIMA S.; FARAH, VERA M. A.. Timing of fructose intake: An important regulator of adiposity. Clinical and Experimental Pharmacology and Physiology, v. 39, n. 1, p. 57-62, JAN 2012. (09/52556-7)

ARAUJO, I. C.; ANDRADE, R. P.; SANTOS, F.; SOARES, E. S.; YOKOTA, R.; MOSTARDA, C.; FIORINO, P.; DE ANGELIS, K.; IRIGOYEN, M. C.; MORRIS, M.; et al. Early developmental exposure to high fructose intake in rats with NaCl stimulation causes cardiac damage. EUROPEAN JOURNAL OF NUTRITION, v. 55, n. 1, p. 83-91, FEB 2016. (09/52556-7)

FIORINO, PATRICIA; EVANGELISTA, FABIANA SANT'ANNA; SANTOS, FERNANDO; MOTTER MAGRI, FATIMA MARIA; DELORENZI, JAN CARLO MORAIS O. B.; GINOZA, MILTON; FARAH, VERA. The Effects of Green Tea Consumption on Cardiometabolic Alterations Induced by Experimental Diabetes. Experimental Diabetes Research, 2012. (11/02126-6, 09/52556-7)