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Electrocardiographic and echocardiographic study of patients with chronic obstructive pulmonary disease

Grant number: 10/10312-1
Support Opportunities:Regular Research Grants
Duration: September 01, 2010 - February 28, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Irma de Godoy
Grantee:Irma de Godoy
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Cigarette smoking is the leading cause of preventable death worldwide. Approximately 50% of all smokers die from smoking-related diseases and about one-third of the adult population smokes. The main tobacco-related diseases are cardiovascular disease (CVD), cancer of various sites and chronic obstructive pulmonary disease (COPD). The overall impact of COPD is increasing and it is estimated that the mortality associated with it will increase about 30% over the next ten years, and that by 2030, COPD will be the fourth leading cause of death worldwide. CVD is currently the leading cause of death worldwide and in nearly half of the cases the etiology is coronary insufficiency. There are several risk factors for CVD; however, several studies suggest smoking as the major modifiable risk factor. The prevalence of complications and mortality from CVD in COPD patients is high. Moreover, the presence of airway obstruction and/or COPD is a predictor of cardiovascular mortality independent of age, sex, total cholesterol, hypertension and smoking history. Systemic inflammation is common in smokers, COPD patients and patients with CVD and may be a mechanism involved in the relationship between airway obstruction and cardiovascular risk. However, despite evidences from epidemiological investigations, few studies have assessed the prevalence of cardiovascular changes in patients with COPD. The hypothesis of the present proposal is that the association between COPD and CVD up regulate systemic inflammation, causes higher impairment of the general health status and functional exercise capacity and increases the dyspnea sensation. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LAURA MIRANDA DE OLIVEIRA CARAM; RENATA FERRARI; CRISTIANE ROBERTA NAVES; LIANA SOUSA COELHO; SIMONE ALVES DO VALE; SUZANA ERICO TANNI; IRMA GODOY. Fatores de risco de doença cardiovascular em pacientes com DPOC: DPOC leve/moderada versus DPOC grave/muito grave. Jornal Brasileiro de Pneumologia, v. 42, n. 3, p. 179-184, . (10/10312-1)
LAURA MIRANDA DE OLIVEIRA CARAM; RENATA FERRARI; CRISTIANE ROBERTA NAVES; SUZANA ERICO TANNI; LIANA SOUSA COELHO; SILMÉIA GARCIA ZANATI; MARCOS FERREIRA MINICUCCI; IRMA GODOY. Association between left ventricular diastolic dysfunction and severity of chronic obstructive pulmonary disease. Clinics, v. 68, n. 6, p. 772-776, . (10/10312-1)

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