Climacteric women HIV seropositive: menopausal symptoms, sexual function, metabolic syndrome and bone mineral density

• Grant number: 10/06037-5
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2010
• End date: April 30, 2013
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Lucia Helena Simões da Costa Paiva
• Grantee: Lucia Helena Simões da Costa Paiva
• Host Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Aarao Mendes Pinto Neto ; Ana Lúcia Ribeiro Valadares ; Eliana Martorano Amaral

Abstract

Due to the HIV positive women increasing longevity, these women are experiencing the menopausal symptoms simultaneously with the metabolic alterations related to the HIV infection and to the use of antiretroviral therapy (HAART), which may influence their well-being and psychological and sexual behaviors. Aiming at knowing the relation between climacteric symptoms, sexual function, metabolic syndrome and bone mineral density with the presence of HIV and its treatment, a cross-sectional study, quantitative in nature is proposed, investigating women aged 40 to 60 years, being 241 HIV-positive and 241 HIV-seronegative. The data collection with be carried on with the use of an interview, clinical examination, and laboratory tests. Climacteric symptoms will be evaluated through the use of Menopause Rating Scale (MRS) questionnaire, and the sexual function through the Short Personal Experiences Questionnaire (SPEQ). The metabolic syndrome will be assessed by waist circumference measurement, serum triglycerides, HDL cholesterol, and blood pressure measurement. Bone mineral density will be measured by the X-ray dual-energy (DXA) absorption, with the use of Hologic. Chi-square and multivariate analysis using Poisson regression will be the statistical instruments for the treatment of quantitative data. It is expected that menopausal symptoms will be more frequent and intense in HIV positive women than in HIV negative, and sexual dysfunction, metabolic syndrome, and osteoporosis will be more prevalent in HIV-positive women as well. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GOMES, DEBORA C.; VALADARES, ANA L. R.; DE MORAES, MONICA J.; LAGRUTTA, BIANCA B.; PINTO-NETO, AARAO M.; COSTA-PAIVA, LUCIA. Low bone mass in human immunodeficiency virus-infected climacteric women receiving antiretroviral therapy: prevalence and associated factors. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, v. 22, n. 2, p. 224-230, FEB 2015. (10/06037-5)

LÍVIA D. AKL; ANA L.R. VALADARES; MONICA JACQUES DE MORAES; AARÃO M. PINTO-NETO; BIANCA LAGRUTTA; LÚCIA COSTA-PAIVA. Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy: prevalence and associated factors. Brazilian Journal of Infectious Diseases, v. 21, n. 3, p. 263-269, 2017-06-00. (10/06037-5)

LUI-FILHO, JEFFREY F.; VALADARES, ANA LUCIA R.; GOMES, DEBORA DE C.; AMARAL, ELIANA; PINTO-NETO, AARAO M.; COSTA-PAIVA, LUCIA. Menopausal symptoms and associated factors in HIV-positive women. MATURITAS, v. 76, n. 2, p. 172-178, OCT 2013. (10/06037-5)

POLITANO, CARLOS A.; VALADARES, ANA L. R.; PINTO-NETO, AARAO; COSTA-PAIVA, LUCIA. The Metabolic Syndrome and Sexual Function in Climacteric Women: A Cross-Sectional Study. Journal of Sexual Medicine, v. 12, n. 2, p. 455-462, FEB 2015. (10/06037-5)