| Grant number: | 10/14830-7 |
| Support Opportunities: | Regular Research Grants |
| Start date: | May 01, 2011 |
| End date: | April 30, 2013 |
| Field of knowledge: | Biological Sciences - Microbiology |
| Principal Investigator: | Maria Cristina Carlan da Silva |
| Grantee: | Maria Cristina Carlan da Silva |
| Host Institution: | Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil |
| Associated researchers: | Manoel Jacobsen Teixeira |
Abstract
Human cytomegalovirus (HCMV) is an important viral pathogen that causes a variety of diseases in imunocompromised individuals and newborns that can culminate in death. Recent evidences indicate that HCMV is involved in tumor progression. Studies demonstrated that the viral DNA and proteins are present in many types of cancer tissues; viral proteins are able to interfere with cell cycle, apoptosis and the immune system. In addition, there are indications that the infection of tumor cells by HCMV increases their malignity. These evidences lead to the creation of the term oncomodulation, defined as the ability of the virus to promote tumor progression. The studies of the HCMV role in the process of tumor malignity are rapidly advancing and a better understanding of the oncomodulation phenomenon is essential to clarify the participation of HCMV in malignity and for the determination of specific viral proteins that can be therapeutic targets in certain tumors types. This project aims the detection HCMV viral replication in brain tumors, as well as the establishment of tumor cell lines and inhibition of the expression of specific viral proteins that are likely involved in tumor malignity to further verify their effect in cell proliferation. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |