Studies of acute phase proteins in dogs and cats with lymphoma

• Grant number: 10/19975-3
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2011
• End date: February 28, 2013
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Sílvia Regina Ricci Lucas
• Grantee: Sílvia Regina Ricci Lucas
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Lymphoma belongs to a group of malignancies that have in common their origin in lymphoreticular cells, and is generally manifested in lymphoid tissues. In the evolution of lymphoma, there is a generalized reaction of the body in a non-specific and acute injury against local and / or systemic diseases that compromise the homeostasis, known as acute phase response, which leads to a significant change in protein synthesis by the liver, resulting in an increase of some proteins known as acute phase proteins. Therefore, taking into account the importance of lymphomas in routine clinical care of dogs and cats, the measurement of serum acute phase proteins, notably alpha-1 acid glycoprotein and serum amyloid A in cats, can be very useful for monitoring chemotherapy in cats with lymphoma as it can be an increase in their serum at the time of diagnosis, decreased during treatment indicates regression of the disease, and increase again during the event monitoring, indicate recurrence of lymphoma, while in dogs we hope to involve high levels of serum C-reative protein with lower survival time in these patients. Thus, the aim of this study is to evaluate serum levels of acute phase proteins serum amyloid A, a1-acid glycoprotein and C-reactive protein in cats with lymphoma during chemotherapy, and a retrospective study of serum levels of C-reactive protein in dogs with lymphoma and its relationship with prognosis. (AU)