Vision and cellular communication in the retina: the role of mixed-input bipolar cells

• Grant number: 10/16469-0
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: August 01, 2011
• End date: July 31, 2016
• Field of knowledge: Humanities - Psychology - Physiological Psychology
• Principal Investigator: Christina Joselevitch
• Grantee: Christina Joselevitch
• Host Institution: Instituto de Psicologia (IP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant(s): 15/04828-9 - A MODELLING APPROACH TO THE INFLUENCE OF CELLULAR GEOMETRY AND THE DISTRIBUTION OF MEMBRANE CHANNELS ONTO NEURONAL INTEGRATION, AV.EXT; 12/01105-8 - The role of distinct cellular compartments in visual processing by mixed-input bipolar cells, AV.EXT
• Associated scholarship(s): 15/12457-0 - Electrophysiological study of an animal model for Retinopathy of Prematurity, BP.MS; 14/17093-4 - Study of the production, composition and outflow of intraocular media in standard and black Moor goldfish (Carassius auratus), BP.MS

Abstract

The sensitivity and adaptability of the visual system to the most varied light environments are impressive. Although a good part of our visual versatility lies in the existence of two types of photoreceptors with different light sensitivities in our retina, the rods and the cones, post-receptoral adaptive mechanisms are paramount to proper visual function, given the limited ability of rods to adapt to light. These post-receptoral gain control mechanisms are however poorly understood. Bipolar cells that receive input from both kinds of photoreceptors are key elements in the visual adaptation process, since they need to actively adjust their dynamic range in order to be able to transmit visual signals to the inner retina continuously under scotopic, mesopic and photopic levels. This project aims to clarify which mechanisms in these mixed-input bipolar cells allow such performance, by investigating the interactions between photoreceptor inputs at different adaptive states, their integration and gain control, the kind of filtering imposed by physiology and morphology of bipolar cells and their mechanisms of synaptic transmission. To answer these questions, we will perform experiments combining electrophysiological, morphological and pharmacological techniques, as well as mathematical modeling, in order to understand the coding strategies of mixed-input ON bipolar cells (mbON). These neurons receive substancial rod input and have, therefore, powerful gain control mechanisms. The results obtained in this study will not only increase our knowledge about retinal coding strategies, but may also have practical implications for the development of therapies for diseases that affect the first visual synapses, such as retinitis pigmentosa, retinoschisis and congenital stationary night blindness. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KAE LEOPOLDO; CHRISTINA JOSELEVITCH. A neurociência computacional no estudo dos processos cognitivos. Psicologia USP, v. 29, n. 1, p. 40-49, 2018-01-00. (10/16469-0)

GUIMARAES-SOUZA, ELISA MARIA; JOSELEVITCH, CHRISTINA; BRITTO, LUIZ ROBERTO G.; CHIAVEGATTO, SILVANA. Retinal alterations in a pre-clinical model of an autism spectrum disorder. MOLECULAR AUTISM, v. 10, APR 15 2019. (10/16469-0, 17/06100-8)

JOSELEVITCH, CHRISTINA; ZENISEK, DAVID. Direct Observation of Vesicle Transport on the Synaptic Ribbon Provides Evidence That Vesicles Are Mobilized and Prepared Rapidly for Release. JOURNAL OF NEUROSCIENCE, v. 40, n. 39, p. 15-pg., 2020-09-23. (10/16469-0)

LEOPOLDO, KAE; KAMERMANS, MAARTEN; JOSELEVITCH, CHRISTINA. Dendritic voltage-gated K+ currents stabilize response amplitude and speed on a computational model of the rod-driven ON bipolar cell. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 60, n. 9, p. 2-pg., 2019-07-01. (10/16469-0)

CORREDOR, VITOR H.; DA SILVA, FLAVIO T.; BARAN, LUIZ C. P.; VENTURA, DORA F.; JOSELEVITCH, CHRISTINA. Distribution and density of mixed-input ON bipolar cells of the goldfish (Carassius auratus) during growth. JOURNAL OF COMPARATIVE NEUROLOGY, v. 527, n. 5, p. 903-915, APR 1 2019. (14/26818-2, 10/16469-0)