Mechanisms of erectile dysfunction on heart failure

• Grant number: 10/17362-4
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: June 01, 2011
• End date: May 31, 2015
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Fernando Silva Carneiro
• Grantee: Fernando Silva Carneiro
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Rita de Cassia Aleixo Tostes Passaglia
• Associated scholarship(s): 11/10430-7 - Mechanisms of erectile dysfunction on heart failure, BP.JP

Abstract

Erectile dysfunction (ED) is extremely high among heart failure (HF) patients. Some studies have shown that the prevalence is around 89%. Many mechanisms have been proposed to cause ED associated with HF. The patient limited capacity to exertion and coronary artery disease as a consequence of the atherosclerotic burden are considered the main mechanisms responsible for HF-associated ED. However, recent studies suggest that another mechanism may be involved. Although ED in HF patients is alarmingly high and the association is clearly established, no experimental or human studies have been reported in the literature to determine the mechanisms involved. Considering the high incidence and prevalence of ED in HF patients and the complex relationship between ED and cardiovascular diseases, it is of vital importance to understand the mechanisms leading to ED in HF to identify new therapeutic targets that can be aimed to improve not only patients life quality, but also survival rates. The present study will test the following hypothesis: 1) HF-induced animals (by coronary artery ligation) display increased cavernosal reactivity to contractile stimuli and decreased relaxation responses, favoring ED; 2) HF-induced animals display ED in vivo; 3) internal pudendal arteries dysfunction contributes to ED in HF; 4) damage-associated molecular patterns (DAMPs) contributes to ED after HF-induced damage. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUES, FERNANDA LUCIANO; FAIS, RAFAEL SOBRANO; TOSTES, RITA C.; CARNEIRO, FERNANDO S.. There is a Link Between Erectile Dysfunction and Heart Failure: It could be Inflammation. CURRENT DRUG TARGETS, v. 16, n. 5, p. 442-450, 2015. (10/17362-4)

RODRIGUES, FERNANDA LUCIANO; SILVA, LUIZ EDUARDO V.; HOTT, SARA CRISTINA; BOMFIM, GISELE F.; AGUIAR DA SILVA, CARLOS ALBERTO; FAZAN, JR., RUBENS; RESSTEL, LEONARDO B. M.; TOSTES, RITA C.; CARNEIRO, FERNANDO S.. Toll-like receptor 9 plays a key role in the autonomic cardiac and baroreflex control of arterial pressure. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 308, n. 8, p. R714-R723, APR 15 2015. (10/17362-4)

BOMFIM, GISELE F.; RODRIGUES, FERNANDA LUCIANO; CARNEIRO, FERNANDO S.. Are the innate and adaptive immune systems setting hypertension on fire?. PHARMACOLOGICAL RESEARCH, v. 117, p. 377-393, MAR 2017. (15/21976-1, 10/17362-4, 16/11988-5)

RODRIGUES, FERNANDA LUCIANO; LOPES, RHEURE ALVES M.; FAIS, RAFAEL SOBRANO; DE OLIVEIRA, LUCAS; PRADO, CIBELE M.; TOSTES, RITA C.; CARNEIRO, FERNANDO S.. Erectile dysfunction in heart failure rats is associated with increased neurogenic contractions in cavernous tissue and internal pudendal artery. Life Sciences, v. 145, p. 9-18, JAN 15 2016. (10/17362-4)

RODRIGUES, FERNANDA LUCIANO; FAIS, RAFAEL S.; PEREIRA, MARLIA G. A. G.; GARCIA-CAIRASCO, NORBERTO; TOSTES, RITA C.; CARNEIRO, FERNANDO S.. Erectile Dysfunction in Wistar Audiogenic Rats Is Associated With Increased Cavernosal Contraction and Decreased Neuronal Nitric Oxide Synthase Protein Expression. UROLOGY, v. 106, AUG 2017. (10/17362-4, 15/21976-1, 05/56447-7, 16/11988-5)