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Mechanisms of erectile dysfunction on heart failure

Grant number: 10/17362-4
Support type:Research Grants - Young Investigators Grants
Duration: June 01, 2011 - May 31, 2015
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Fernando Silva Carneiro
Grantee:Fernando Silva Carneiro
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Rita de Cassia Aleixo Tostes Passaglia
Associated scholarship(s):11/10430-7 - Mechanisms of erectile dysfunction on heart failure, BP.JP

Abstract

Erectile dysfunction (ED) is extremely high among heart failure (HF) patients. Some studies have shown that the prevalence is around 89%. Many mechanisms have been proposed to cause ED associated with HF. The patient limited capacity to exertion and coronary artery disease as a consequence of the atherosclerotic burden are considered the main mechanisms responsible for HF-associated ED. However, recent studies suggest that another mechanism may be involved. Although ED in HF patients is alarmingly high and the association is clearly established, no experimental or human studies have been reported in the literature to determine the mechanisms involved. Considering the high incidence and prevalence of ED in HF patients and the complex relationship between ED and cardiovascular diseases, it is of vital importance to understand the mechanisms leading to ED in HF to identify new therapeutic targets that can be aimed to improve not only patients life quality, but also survival rates. The present study will test the following hypothesis: 1) HF-induced animals (by coronary artery ligation) display increased cavernosal reactivity to contractile stimuli and decreased relaxation responses, favoring ED; 2) HF-induced animals display ED in vivo; 3) internal pudendal arteries dysfunction contributes to ED in HF; 4) damage-associated molecular patterns (DAMPs) contributes to ED after HF-induced damage. (AU)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES, FERNANDA LUCIANO; FAIS, RAFAEL S.; PEREIRA, MARLIA G. A. G.; GARCIA-CAIRASCO, NORBERTO; TOSTES, RITA C.; CARNEIRO, FERNANDO S. Erectile Dysfunction in Wistar Audiogenic Rats Is Associated With Increased Cavernosal Contraction and Decreased Neuronal Nitric Oxide Synthase Protein Expression. UROLOGY, v. 106, AUG 2017. Web of Science Citations: 0.
BOMFIM, GISELE F.; RODRIGUES, FERNANDA LUCIANO; CARNEIRO, FERNANDO S. Are the innate and adaptive immune systems setting hypertension on fire?. PHARMACOLOGICAL RESEARCH, v. 117, p. 377-393, MAR 2017. Web of Science Citations: 13.
RODRIGUES, FERNANDA LUCIANO; LOPES, RHEURE ALVES M.; FAIS, RAFAEL SOBRANO; DE OLIVEIRA, LUCAS; PRADO, CIBELE M.; TOSTES, RITA C.; CARNEIRO, FERNANDO S. Erectile dysfunction in heart failure rats is associated with increased neurogenic contractions in cavernous tissue and internal pudendal artery. Life Sciences, v. 145, p. 9-18, JAN 15 2016. Web of Science Citations: 3.
RODRIGUES, FERNANDA LUCIANO; SILVA, LUIZ EDUARDO V.; HOTT, SARA CRISTINA; BOMFIM, GISELE F.; AGUIAR DA SILVA, CARLOS ALBERTO; FAZAN, JR., RUBENS; RESSTEL, LEONARDO B. M.; TOSTES, RITA C.; CARNEIRO, FERNANDO S. Toll-like receptor 9 plays a key role in the autonomic cardiac and baroreflex control of arterial pressure. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 308, n. 8, p. R714-R723, APR 15 2015. Web of Science Citations: 8.
RODRIGUES, FERNANDA LUCIANO; FAIS, RAFAEL SOBRANO; TOSTES, RITA C.; CARNEIRO, FERNANDO S. There is a Link Between Erectile Dysfunction and Heart Failure: It could be Inflammation. CURRENT DRUG TARGETS, v. 16, n. 5, p. 442-450, 2015. Web of Science Citations: 7.

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