Abstract
The primary objective of this proposal is to maintain the excellence of natural products and materials research at the Institute of Chemistry - UNESP and its partner UNESP and UNAERP institutions. This multi-user consortium, which already has two nuclear magnetic resonance (NMR) spectrometers (Inov A-500 and Inov A-300, both in steady operation for the last 10 years), envisions the setup of a center that is highly specialized in advanced NMR studies. The acquisition of three news equipment: superconducting fourier NMR spectrometer avance IIITM 600-MHz with cryo probe and sample preparation robot, superconducting FT-NMR spectrometer avance IIITM 400 MHz and 300 MHz Fourier NMR spectrometer with dual 13C/ 1 H probe spectrometers will allow NMR spectra to be obtained, using unidimensional and bidimensional pulse sequences among other various modern NMR techniques such as broad band, distortionless enhancement by polarization transfer, insensitive nuclei enhanced by polarization transfer, heteronuclear and homonuclear correlations, long range coupling, heteronuclear correlations, single quantum coherence, heteronuclear multiple quantum and bond coherence and, diffusion ordered spectroscopy. All those experiments can be carried out with or without temperature variations or pulsed field gradient selections. These techniques will be employed in the structural characterization (at the molecular or micromolecular level) of metabolites from natural sources (from animals, plants, or microorganisms, by organic or inorganic synthesis) that are of pharmacological interest, as well as the characterization of vitreous materials, ceramics, polymers, and organic/inorganic complexes of academic, scientific or industrial interest. These studies are related to academic research and projects for innovation and development (through business-academic partnerships). Consequently, these studies will contribute for the development of graduate programs in Brazil, to the advancement of Brazilian scientific production aiming a greater exposure of national research on the international stage, and to the development of human resources, as well as for sustainable development of science and technology in our country. (AU)
Scientific publications(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SELEGATO, DENISE MEDEIROS;
FREIRE, RAFAEL TEIXEIRA;
PILON, ALAN CESAR;
BIASETTO, CAROLINA RABAL;
DE OLIVEIRA, HAROLDO CESAR;
DE ABREU, LUCAS MAGALHAES;
ARAUJO, ANGELA REGINA;
BOLZANI, VANDERLAN DA SILVA;
CASTRO-GAMBOA, IAN.
Improvement of bioactive metabolite production in microbial cultures-A systems approach by OSMAC and deconvolution-based (HNMR)-H-1 quantification.
Magnetic Resonance in Chemistry,
v. 57,
n. 8,
p. 458-471,
AUG 2019.
Web of Science Citations: 0.