Acquisition of a flow cytometer and computed tomography scanner for the development of a multi-user facility for obesity, malnutrition, mitochondrial alterations and insulin secretion process

• Grant number: 09/54121-8
• Support Opportunities: Multi-user Equipment Program
• Start date: October 01, 2010
• End date: September 30, 2014
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Antonio Carlos Boschiero
• Grantee: Antonio Carlos Boschiero
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• EMU web page: Página do Equipamento Multiusuário não informada
• Type of equipment: Tipo de Equipamento Multiusuário não informado
• Manufacturer: Fabricante não informado
• Model: Modelo não informado

Abstract

This proposal has the following objectives: 1) study of the mechanisms of pancreatic beta cell destruction during the early phases of type 2 diabetes (the search for strategies to inhibit that process, as well as to recover the cell mass in different animal models); 2) morphofunctional characterization of the pancreatic islets of mice submitted to protein restriction or to a high-lipid diet and receiving taurine supplementation; 3) energy metabolism, intracellular calcium homeostasis, and mitochondrial oxidative stress in cell death; and 4) inflammation and immune response in obesity. (AU)