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Involvement of Metabolic Coupling Factors on insulin secretion process in undernourished mice submited to experimental obesity

Grant number: 11/20196-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): August 31, 2016
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Everardo Magalhães Carneiro
Grantee:Renato Chaves Souto Branco
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):13/25071-8 - Investigation of the effects of taurine on the pancreatic islets overexpressing glucokinase, BE.EP.DR

Abstract

The insulin secretion can be stimulated by many nutrients, neurotransmitters and peptide hormones, however, its main secretagogue is the glucose. Obesity and malnourishment are related to energetic homeostasis imbalance, leading to dysfunction of pancreatic beta-cells. Rodents submitted to protein malnourishment after weaning, shows alterations on insulin secretion process. It was observed many molecular alterations of glucose-induced insulin secretion (GIIS) caused by low protein diet. On the other hand, under protein malnourishment conditions, the alterations in the control of metabolites involved in GIIS modulation are still unknown. Nevertheless, evidences suggest that alterations in the coupling between the glycolytic pathway and mitochondrial metabolism, damaging ATP production and other metabolic coupling factors (MCFs) in the pancreatic beta-cells, resulting in changes on insulin secretion. The loss of coupling between glycolysis and mitochondrial metabolism has been pointed as one of the factors related to development of others diseases, as obesity and diabetes. Both low-calorie diets as hyperlipidic diets during important stages of development, induce a series of changes in glucose metabolism in pancreatic islets, however, the association between these two treatments have not yet been investigated. Therefore, the aim of this study is to investigate the molecular mechanisms involved in metabolic control of GIIS in malnourished animals subsequently induced to experimental obesity.

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BRANCO, Renato Chaves Souto. Protein malnutrition prevents the effects of taurine on secretion and action of insulin in obese mice : participation of the taurine transporter. 2016. Doctoral Thesis - Universidade Estadual de Campinas, Instituto de Biologia.

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