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Acquisition of a flow cytometer and computed tomography scanner for the development of a multi-user facility for obesity, malnutrition, mitochondrial alterations and insulin secretion process

Grant number: 09/54121-8
Support Opportunities:Multi-user Equipment Program
Duration: October 01, 2010 - September 30, 2014
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Antonio Carlos Boschiero
Grantee:Antonio Carlos Boschiero
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável
EMU web page: Página do Equipamento Multiusuário não informada
Type of equipment: Tipo de Equipamento Multiusuário não informado
Manufacturer: Fabricante não informado
Model: Modelo não informado

Abstract

This proposal has the following objectives: 1) study of the mechanisms of pancreatic beta cell destruction during the early phases of type 2 diabetes (the search for strategies to inhibit that process, as well as to recover the cell mass in different animal models); 2) morphofunctional characterization of the pancreatic islets of mice submitted to protein restriction or to a high-lipid diet and receiving taurine supplementation; 3) energy metabolism, intracellular calcium homeostasis, and mitochondrial oxidative stress in cell death; and 4) inflammation and immune response in obesity. (AU)

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