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Immuno-expression of Smac/Diablo, AIF, cytochrome c, cleaved caspase 3 and Ki-67 in gastric cancer tissue by tissue micro array (TMA)

Grant number: 10/15764-8
Support type:Regular Research Grants
Duration: June 01, 2011 - November 30, 2012
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal Investigator:Celina Tizuko Fujiyama Oshima
Grantee:Celina Tizuko Fujiyama Oshima
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers: Larissa Comparini da Silva ; Nora Manoukian Forones ; Ricardo Artigiani Neto ; Thiago Simao Gomes


The processes of proliferation and cell death are important in tumor development. Both are crucial for both biological activities and pathological physiological processes. Apoptosis plays a key role in maintaining the integrity of gastrointestinal mucosa and its deregulation is associated with the occurrence of lesions such as atrophic gastritis, peptic ulcer, intestinal metaplasia, dysplasia and eventually gastric cancer. Increased rate of apoptosis may be stimulus for compensatory hyperproliferative response in an attempt to maintain the gastric mucosal cell mass. It is suggested that, since the proliferation is established, an increase in the rate of cell cycle may predispose the gastric epithelium to genotoxic and mutagenic damage. The protein Smac / Diablo is present in the inner mitochondrial membrane where after being released has the function to inhibit the IAPS (apoptosis inhibitory protein), cytochrome c is released after the destabilization of the mitochondrial membrane to form the apoptosome function to connect with the Apaf-1 and caspase 9, and these two proteins induce apoptosis, since the AIF (apoptosis inducing factor) is also present in the mitochondrial membrane and released after their destabilization induces apoptosis independent of caspases. Study these proteins and cleaved caspase-3 and Ki-67 may predict levels of proliferation and cell death rate during gastric carcinogenesis. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, LARISSA COMPARINI; FORONES, NORA MANOUKIAN; RIBEIRO, DANIEL ARAKI; MIKI IHARA, SILVIA SAULI; GOMES, THIAGO SIMAO; NETO, RICARDO ARTIGIANI; FUJIYAMA OSHIMA, CELINA TIZUKO. Immunoexpression of DIABLO, AIF and Cytochrome c in Gastric Adenocarcinoma Assessed by Tissue Microarray. ANTICANCER RESEARCH, v. 33, n. 2, p. 647-653, FEB 2013. Web of Science Citations: 2.

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