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Development of green chemistry strategies on chromatography and application to the evaluation of antibiotics degradation in wastewaters by fixed-bed anaerobic bioreactors


Wastewater contamination with pharmaceutical drugs is of remarkable importance. Among other drugs, antibiotics cause concern due to their hole in bacterial resistance. Effluents from industries, residential districts, hospitals and animal farms are the main sources of contamination by antibiotics. Moreover, conventional wastewater treatments have shown low efficiency in the removal of these xenobiotics, while alternative options for that treatment have few studies and their consequences are not clearly evaluated. Still regarding environmental concerns, the Green Chemistry has been driving modernization of analytical strategies. In the scope of pharmaceutical drugs analysis in complex matrices, invaluable importance is conferred to the development and application of miniaturized sample preparation and chromatographic separation. Currently, several strategies of solid phase or liquid phase microextraction can be developed for wastewater samples, and capillary liquid chromatography with fast and very efficient columns are greatly recommended by the Green Analytical Chemistry. Thus, the aims of this project are the development of modern strategies for the sample preparation of wastewaters containing antibiotics; the separation and detection of these compounds to the trace level using capillary liquid chromatography; and, the application of these methodologies to the evaluation of the degradation of them with fixed-bed biological reactors. (AU)

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Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VARGAS MEDINA, DEYBER ARLEY; SANTOS-NETO, ALVARO JOSE; CERDA, VICTOR; MAYA, FERNANDO. Automated dispersive liquid-liquid microextraction based on the solidification of the organic phase. Talanta, v. 189, p. 241-248, . (16/21950-5, 10/19910-9, 17/02147-0)
SARTORE, DOUGLAS MORISUE; VARGAS MEDINA, DEYBER ARLEY; COSTA, JOSE LUIZ; LANCAS, FERNANDO MAURO; SANTOS-NETO, ALVARO JOSE. Automated microextraction by packed sorbent of cannabinoids from human urine using a lab-made device packed with molecularly imprinted polymer. Talanta, v. 219, . (17/02147-0, 19/22724-7, 10/19910-9)
ANDRADE, FELIPE NASCIMENTO; SANTOS-NETO, ALVARO JOSE; LANCAS, FERNANDO MAURO. Microextraction by packed sorbent liquid chromatography with time-of-flight mass spectrometry of triazines employing a molecularly imprinted polymer. JOURNAL OF SEPARATION SCIENCE, v. 37, n. 21, p. 3150-3156, . (10/19910-9, 11/09898-4)
LIMA GOMES, PAULO C. F.; TOMITA, INS N.; SANTOS-NETO, ALVARO J.; ZAIAT, MARCELO. Rapid determination of 12 antibiotics and caffeine in sewage and bioreactor effluent by online column-switching liquid chromatography/tandem mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 407, n. 29, p. 8787-8801, . (09/15984-0, 10/19910-9, 12/07153-4)
RODRIGUEZ CABAL, LUIS FELIPE; VARGAS MEDINA, DEYBER ARLEY; LIMA, ADRIEL MARTINS; LANCAS, FERNANDO MAURO; SANTOS-NETO, ALVARO JOSE. Robotic-assisted dynamic large drop microextraction. Journal of Chromatography A, v. 1608, . (17/02147-0, 16/21950-5, 10/19910-9)
AKAMINE, LIDIA AKEMI; MEDINA, DEYBER ARLEY VARGAS; LANCAS, FERNANDO MAURO. Magnetic solid-phase extraction of gingerols in ginger containing products. Talanta, v. 222, . (17/02147-0, 10/19910-9, 19/22724-7)
RODRIGUEZ CABAL, LUIS FELIPE; VARGAS MEDINA, DEYBER ARLEY; COSTA, JOSE LUIZ; LANCAS, FERNANDO MAURO; SANTOS-NETO, ALVARO JOSE. Determination of ring-substituted amphetamines through automated online hollow fiber liquid-phase microextraction-liquid chromatography. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 411, n. 29, p. 7889-7897, . (17/02147-0, 18/00432-1, 16/21950-5, 10/19910-9)
VARGAS MEDINA, DEYBER ARLEY; RODRIGUEZ CABAL, LUIS FELIPE; TITATO, GUILHERME MIOLA; LANCAS, FERNANDO MAURO; SANTOS-NETO, ALVARO JOSE. Automated online coupling of robot-assisted single drop microextraction and liquid chromatography. Journal of Chromatography A, v. 1595, p. 66-72, . (16/21950-5, 10/19910-9, 17/02147-0)
FIGUEROLA, ANDREU; MEDINA, DEYBER A. V.; SANTOS-NETO, ALVARO J.; CABELLO, CARLOS PALOMINO; CERDA, VICTOR; PALOMINO, GEMMA TURNES; MAYA, FERNANDO. Metal-organic framework mixed-matrix coatings on 3D printed devices. APPLIED MATERIALS TODAY, v. 16, p. 21-27, . (16/21950-5, 10/19910-9)
CHATILA, SAMI; AMPARO, MAURA R.; CARVALHO, LUCAS S.; PENTEADO, EDUARDO D.; TOMITA, INES N.; SANTOS-NETO, ALVARO J.; LIMA GOMES, PAULO C. F.; ZAIAT, MARCELO. Sulfamethoxazole and ciprofloxacin removal using a horizontal-flow anaerobic immobilized biomass reactor. ENVIRONMENTAL TECHNOLOGY, v. 37, n. 7, p. 847-853, . (09/15984-0, 10/19910-9, 11/04527-8, 12/07153-4)
OLIVEIRA, G. H. D.; SANTOS-NETO, A. J.; ZAIAT, M.. Evaluation of sulfamethazine sorption and biodegradation by anaerobic granular sludge using batch experiments. Bioprocess and Biosystems Engineering, v. 39, n. 1, p. 115-124, . (12/18942-0, 09/53850-6, 10/19910-9)
FUMES, BRUNO HENRIQUE; ANDRADE, FELIPE NASCIMENTO; DOS SANTOS NETO, ALVARO JOSE; LANCAS, FERNANDO MAURO. Determination of pesticides in sugarcane juice employing microextraction by packed sorbent followed by gas chromatography and mass spectrometry. JOURNAL OF SEPARATION SCIENCE, v. 39, n. 14, p. 2823-2830, . (14/07347-9, 10/19910-9, 11/09898-4, 13/17425-4)

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Filed patent(s) as a result of this research project

MICRODISPOSITIVO DE EXTRAÇÃO DESMONTÁVEL PARA ADAPTAÇÃO A MICROSSERINGAS DE AGULHA REMOVÍVEL BR1020130254517 - Universidade de São Paulo (USP) . Alvaro José dos Santos Neto; Fernando Mauro Lancas; Alex Sandro Contadori; Scarlet Nere Ortega; Maura Roquete Amparo - October 2013, 02