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Importance of local damage induced by snake venom metalloproteinases in the induction of thrombocytopenia in envenomations

Grant number: 10/52559-3
Support type:Regular Research Grants
Duration: August 01, 2011 - July 31, 2013
Field of knowledge:Biological Sciences - Pharmacology
Cooperation agreement: CONICET
Principal Investigator:Marcelo Larami Santoro
Grantee:Marcelo Larami Santoro
Principal investigator abroad: María Elisa Peichoto
Institution abroad: Universidad Nacional del Nordeste (UNNE), Argentina
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:10/08162-1 - Contribution of local injury evoked by Bothrops jararaca snake venom to the genesis of systemic hemostatic disturbances, AP.R
Articles published in Agência FAPESP Newsletter about the research grant
Study on jararaca bites helps to elucidate the mechanisms of bleeding  

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ELISA PEICHOTO, MARIA; SANTORO, MARCELO LARAMI. Patagonfibrase modifies protein expression of tissue factor and protein disulfide isomerase in rat skin. Toxicon, v. 119, p. 330-335, SEP 1 2016. Web of Science Citations: 4.
YAMASHITA, KARINE M.; ALVES, ANDRE F.; BARBARO, KATIA C.; SANTORO, MARCELO L. Bothrops jararaca Venom Metalloproteinases Are Essential for Coagulopathy and Increase Plasma Tissue Factor Levels during Envenomation. PLoS Neglected Tropical Diseases, v. 8, n. 5 MAY 2014. Web of Science Citations: 23.
SANCHEZ, M. N.; TIMONIUK, A.; MARUNAK, S.; TEIBLER, P.; ACOSTA, O.; PEICHOTO, M. E. Biochemical and biological analysis of Philodryas baroni (Baron's Green Racer; Dipsadidae) venom: Relevance to the findings of human risk assessment. HUMAN & EXPERIMENTAL TOXICOLOGY, v. 33, n. 1, p. 22-31, JAN 2014. Web of Science Citations: 10.
ELISA PEICHOTO, MARIA; ZYCHAR, BIANCA CESTARI; LUIZ TAVARES, FLAVIO; GONCALVES, LUIS ROBERTO CAMARGO; ACOSTA, OFELIA; SANTORO, MARCELO LARAMI. Inflammatory effects of patagonfibrase, a metalloproteinase from Philodryas patagoniensis (Patagonia Green Racer; Dipsadidae) venom. Experimental Biology and Medicine, v. 236, n. 10, p. 1166-1172, OCT 2011. Web of Science Citations: 10.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.