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Importance of local damage induced by snake venom metalloproteinases in the induction of thrombocytopenia in envenomations

Grant number: 10/52559-3
Support Opportunities:Regular Research Grants
Start date: August 01, 2011
End date: July 31, 2013
Field of knowledge:Biological Sciences - Pharmacology - Toxicology
Agreement: CONICET
Principal Investigator:Marcelo Larami Santoro
Grantee:Marcelo Larami Santoro
Principal researcher abroad: María Elisa Peichoto
Institution abroad: Universidad Nacional del Nordeste (UNNE), Argentina
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:10/08162-1 - Contribution of local injury evoked by Bothrops jararaca snake venom to the genesis of systemic hemostatic disturbances, AP.R
Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ELISA PEICHOTO, MARIA; SANTORO, MARCELO LARAMI. Patagonfibrase modifies protein expression of tissue factor and protein disulfide isomerase in rat skin. Toxicon, v. 119, p. 330-335, . (10/08162-1, 10/52559-3, 13/25177-0)
SANCHEZ, M. N.; TIMONIUK, A.; MARUNAK, S.; TEIBLER, P.; ACOSTA, O.; PEICHOTO, M. E.. Biochemical and biological analysis of Philodryas baroni (Baron's Green Racer; Dipsadidae) venom: Relevance to the findings of human risk assessment. HUMAN & EXPERIMENTAL TOXICOLOGY, v. 33, n. 1, p. 22-31, . (10/52559-3)
ELISA PEICHOTO, MARIA; ZYCHAR, BIANCA CESTARI; LUIZ TAVARES, FLAVIO; GONCALVES, LUIS ROBERTO CAMARGO; ACOSTA, OFELIA; SANTORO, MARCELO LARAMI. Inflammatory effects of patagonfibrase, a metalloproteinase from Philodryas patagoniensis (Patagonia Green Racer; Dipsadidae) venom. Experimental Biology and Medicine, v. 236, n. 10, p. 1166-1172, . (08/02996-8, 10/52559-3, 10/08162-1)
YAMASHITA, KARINE M.; ALVES, ANDRE F.; BARBARO, KATIA C.; SANTORO, MARCELO L.. Bothrops jararaca Venom Metalloproteinases Are Essential for Coagulopathy and Increase Plasma Tissue Factor Levels during Envenomation. PLoS Neglected Tropical Diseases, v. 8, n. 5, . (10/08162-1, 10/02568-6, 10/52559-3)