Conformational and electronic interaction studies of some classes of mono- and di-substituted carbonyl compounds at the alpha position

• Grant number: 11/03186-2
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2011
• End date: July 31, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Paulo Roberto Olivato
• Grantee: Paulo Roberto Olivato
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The main purpose of this project is to study the various types of interactions which govern the stability of a particular molecular conformation and, consequently, are responsible for the observed macroscopic properties of the substance. In order to achieve these objectives, the conformational equilibria of selected model compounds will be studied along with the most important effects which determines the stability of a given conformation i.e. anomeric, hyperconjugative and gauche and intramolecular hydrogen bonds. This study will be focused on the following beta-thiosubstituted-carbonyl compounds: (a) 5-substituted- 2-(ethylthioacetyl)-, 2-(ethysulfinylacetyl)- and 2-(ethylsulfonylacetyl)-furans and -thiophenes; (b) para-substituted alpha- phenylsulfinyl- and alpha-phenylsuflonyl-N-methyl-delta-valeroctams; (c) para-substituted (alpha-phenylseleno-alpha-ethylsulfinyl)-acetophenones and (d) 4'-substituted 2-(ethylsulfonyl) phenylacetates. The conformational analysis will be performed according to the methodology previously developed in our laboratories, involving experimental measurements by infrared spectroscopy in conjunction with theoretical calculations of the geometries and energies of the conformers in the gas and in the solution phase as well. Studies on the orbital interactions which stabilize the main conformations will be performed through the NBO method (Natural Bond Orbital). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUES, DANIEL N. S.; OLIVATO, PAULO R.; RODRIGUES, ALESSANDRO; DAL COLLE, MAURIZIO. Conformational analysis and electronic interactions of some 2-ethylsulfinyl-(4 `-substituted)-phenylacetates. Journal of Molecular Structure, v. 1108, p. 245-256, MAR 15 2016. (11/03186-2)

RODRIGUES, DANIEL N. S.; OLIVATO, PAULO R.; RODRIGUES, ALESSANDRO; DAL COLLE, MAURIZIO. Conformational analysis and electronic interactions of some 2-ethylsulfinyl-(4 '-substituted)-phenylacetates. Journal of Molecular Structure, v. 1108, p. 12-pg., 2016-03-15. (11/03186-2)