Evaluation of the fibrinolitic/prothrombotic state in obese children

• Grant number: 11/08101-5
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2013
• End date: May 31, 2016
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Durval Damiani
• Grantee: Durval Damiani
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Ariane de Almeida Puzzello ; Marina Pereira Ybarra Martins de Oliveira

Abstract

In all age groups in Pediatrics has been increase in the prevalence of obesity. Data from NHANES (2003-2004) show that, in the USA, 17.1% of the children and adolescents are obese. In Brazilian children, data from the Brazilian Institute of Geography and Statistics, in the same age range, overweight and obesity increased from 4 to 13% (1970 and 1997, respectively).Currently, 15% of Brazilian children and adolescents are obese, varying widely among the different regions of the country.The increase of adipose tissue results in pathological processes implying inflammation, insulin resistance, hypertension, and dyslipidemia, which can lead to atherosclerosis. The coexistence of metabolic disturbances with coagulation problems form the basis of the coronary heart disease in adult life. Recently, obesity has been associated to hemostatic alterations with clotting stimulation and inadequate fibrinolysis. The prothrombotic state, seen in obesity and in insulin-resistant states is due to the involvement of tissue factor (FT), fibrinogen, factors VII and VIII. On the other hand, the impaired fibrinolysis implies PAI-1 (plasmonogen activator inhibitor 1)and TAFI (Thrombin activation fibrinolysis inhibition), both present in the coagulation cascade. The primary aim of this study is to evaluate the prothrombotic state and adipokines in obese patients (AU)