Influence of polymorphisms of taste receptors genes CD36 and TAS1R2 in diet and metabolic profile in obese children and adolescents.

• Grant number: 13/08255-8
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): August 01, 2013
• Effective date (End): July 31, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Marcio Corrêa Mancini
• Grantee: Marina Brosso Pioltine
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The childhood obesity is a major public health problem and it has a direct impact on the quality of life of children and adolescents, as well as the future risk for development of chronic diseases. The dietary pattern rich in fats and sugars associated to the low intake of dietary fibers, vitamins and minerals is widespread for the rise of obesity. However the factors that contribute to the preference for foods rich in these nutrients are not well established. The taste is recognized as an important predictor of food choices, and polymorphisms in genes encoding its receptors may explain the variability of taste preference and food intake on population. In order to contribute to studies in this area, the aim of this research is to evaluate the influence of polymorphisms of genes CD36 and TAS1R2 in diet and metabolic profile in obese children and adolescents. Then will be conducted a cross-sectional study with participants of both genders, including 500 obese children and adolescents and a control-group of 150 eutrophic children. Will be performed the molecular study of genes CD36 and TAS1R2 and its variants (rs1761667, rs1527483 and rs9701796, rs35874116, respectively), as well as the analysis of food consumption, compulsive eating behavior and metabolic profile.