Production of botulinic serum, toxins and vaccines

• Grant number: 95/03525-7
• Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE
• Start date: June 01, 1996
• End date: December 31, 1999
• Field of knowledge: Biological Sciences - Biochemistry
• Principal Investigator: Isaias Raw
• Grantee: Isaias Raw
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Company: Solvay Saúde Animal Ltda
• City: São Paulo

Abstract

The aim of this project was to develop and set up a unit for the production of botulinic toxins, with a 50 liter fermenter and downstream processing, aimed at: 1) producing botulinic toxins A, B, E of medium grade purity intended for the production of antibotulinic serum for supply to the National Health Foundation and the requirements of other countries. The product would be produced by the institute and commercialized by the Funda- ção Butantan; 2) producing botulinic anatoxins C and D intended, respectively, to immunize birds (or horses) and cattle, and to be commercialized by the Solvay company; 3) producing botulinic toxins A and B of high quality for clinical and scientific use. These products would be commercialized by the Fundação Butantan. (AU)