Microencapsulation of human pancreatic islets and tissue engineering as an alternative therapy of Diabetes mellitus

• Grant number: 99/06460-4
• Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE
• Start date: February 01, 2000
• End date: April 30, 2008
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Principal Investigator: Mari Cleide Sogayar
• Grantee: Mari Cleide Sogayar
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Company: Biobras S/A
• City: São Paulo

Abstract

The isolation, purification and microencapsulation of pancreatic islands constitute a promising alternative in the treatment of Diabetes mellitus (DM). This project aimed: 1) to optimize and perfect the isolation, purification and cryopreservation of human pancreatic islands derived from organs taken from donor cadavers; 2) to reconstitute the microenvironment by means of the co-cultivation of isolated islands with cells of the pancreatic tissue, in the absence and presence of the extracellular matrix, so as to maximize its survival and functionality; 3) to microencapsulate the isolated islands using previously designed biocompatible materials and/or new materials resulting from tissue engineering; and 4) to analyze the functional activity of the microencapsulated islands both in vitro and in vivo. The development of this project should permit the creation of products (biomaterials for the production of microcapsules) and processes (technology for the microencapsulation of pancreatic islands), opening up, thus, a new and revolutionary treatment perspective for diabetic patients. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TAKAMORI‚ E.R.; CRUZ‚ R.; GONÇALVEZ‚ F.; ZANETTI‚ R.V.; ZANETTI‚ A.; GRANJEIRO‚ J.M.. Effect of roughness of zirconia and titanium on fibroblast adhesion. ARTIFICIAL ORGANS, v. 32, n. 4, p. 305-309, 2008. (99/06460-4, 01/10707-7)

ESTHER RIEKO TAKAMORI; EDUARDO ALEIXO FIGUEIRA; RUMIO TAGA; MARI CLEIDE SOGAYAR; JOSÉ MAURO GRANJEIRO. Evaluation of the cytocompatibility of mixed bovine bone. Brazilian Dental Journal, v. 18, n. 3, p. 179-184, 2007-00-00. (01/10707-7, 99/06460-4)

Filed patent(s) as a result of this research project