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Alternative therapies for T1DM: generation of innovative biomaterials for microencapsulation of islets of Langerhans and clusters from mESCs differentiation and functional analysis of genes differentially expressed

Grant number: 13/00664-6
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): May 01, 2013
Effective date (End): May 31, 2018
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Mari Cleide Sogayar
Grantee:Camila Leal Lopes da Silva
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):15/22206-5 - Assessing thioredoxin binding protein (TXNIP) gene influence in zebrafish pancreatic development, BE.EP.DD


Type 1 Diabetes Mellitus (T1DM) is a syndrome characterized by autoimmune destruction of pancreatic beta cells. The transplantation of islets isolated from pancreatic tissue is proposed as an alternative therapy for T1DM, reducing hyperglycemic complications, moreover, it is a process lesser invasive and immunogenic than whole organ transplantation. However, regarding to allotransplantation, an immunosuppressive continuous drug regimen is required to prevent rejection and it is also subject to the shortage of donor organs. Another alternative is the differentiation of murine embryonic stem cells (mESCs) in insulin-producing cell clusters, which mimic the pancreatic cells interactions. The microencapsulation of clusters using biocompatible materials creates an environment immunoprotected that simulates the cellular interactions of the pancreatic tissue, eliminating the need for immunosuppressive drugs. New compounds may be added to the capsules, to optimize cell functions and promote final maturation of clusters. Identification and functional characterization of differentially expressed genes in this process can increase its efficiency. This project aims to: a) promote the final maturation in vivo of cell clusters in a microenvironment immuneprotected and functional of innovative microcapsules and b) analyze the process of beta-pancreatic differentiation, at the molecular level, through the functional analysis of genes repressed during this differentiation. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEAL-LOPES, CAMILA; GRAZIOLI, GISELLA; MARES-GUIA, THIAGO R.; COELHO-SAMPAIO, TATIANA; SOGAYAR, MARI CLEIDE. Polymerized laminin incorporation into alginate-based microcapsules reduces pericapsular overgrowth and inflammation. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v. 13, n. 10, . (16/05311-2, 13/00664-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Camila Leal Lopes da. Alternative therapies for type 1 diabetes mellitus: functional characterization of Txnip gene during -pancreatic differentiation and generation of an innovative biomaterial for cell microencapsulation. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.

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