Chronic obstructive pulmonary disease in patients referred for coronary CT and association between airway obstruction and coronary calcium score

• Grant number: 11/02814-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2011
• End date: May 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Alberto Cukier
• Grantee: Alberto Cukier
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Carlos Eduardo Rochitte ; Frederico Leon Arrabal Fernandes ; João Marcos Salge ; Rafael Stelmach

Abstract

Several studies show an association between COPD and ischemic heart disease (IHD). Besides risk factors such as smoking, both are associated with physical inactivity, advanced age and systemic inflammationThe use of coronary computed tomography (CCT) with multiple detectors is a diagnostic method for coronary disease, describing the anatomy and severity of arterial obstruction. One way of estimating the cardiovascular risk is coronary calcium score (CCS). Due to the association between COPD and IHD, it is likely that many patients with IHD diagnosed by CT have reduced lung function.The aim of this cross-sectional study is to establish the correlation between the ECC and lung function. It will also correlate the presence of irreversible airway obstruction with significant coronary lesions. Patients over 40 years referred to CCT who agree to participate in the study will perform a spirometry with bronchodilator and collect a blood sample to measure serum markers of inflammation and cardiovascular risk (glycemia, lipid profile, CRP, TNF-alpha and fibrinogen). The data will be compared in the general population and in subgroups: smokers, former smokers and nonsmokers.The concomitant assessment of lung function and CCS can contribute knowledge about the epidemiological association between COPD and IHD. This can also add to evidence for the use of spirometry as a marker of cardiovascular risk (AU)