Retrieval of autobiographical memory and the aging brain: a study using functional magnetic resonance

• Grant number: 11/00475-3
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2011
• End date: July 31, 2014
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Geraldo Busatto Filho
• Grantee: Geraldo Busatto Filho
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Ana Carolina Brocanello Regina ; Edson Amaro Junior ; Luiz Roberto Kobuti Ferreira ; Maria da Graça Morais Martin

Abstract

Functional magnetic resonance imaging (fMRI) allows the study of brain function and has provided important information about the cognitive decline associated with aging. Specific studies on the neurofunctional changes of autobiographical memory during aging are needed in order to clarify the neurophysiology of memory decline. Objectives: 1) to assess the correlation between autobiographical memory performance and activation of brain structures; 2) to determine the brain regions where there are differences in brain activation and deactivation between groups of young, middle-aged and elderly during retrieval of autobiographical events; 3) to identify differences between groups regarding functional connectivity during rest. Methods: healthy adults (20 elderly, 20 middle-aged and 20 young) will undergo fMRI during rest and two tasks: visual fixation and retrieval of autobiographical events. The images will be processed with the software SPM8, the two tasks will be contrasted and a correlation map between activation amplitude and performance on the task will be built. Images from each group will be analyzed both independently and through comparison between groups. The resting state data will be assessed using independent component analysis to identify the default mode network. Between-group comparisons will investigate differences in connectivity between the components of this network. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, LUIZ KOBUTI; BROCANELLO REGINA, ANA CAROLINA; KOVACEVIC, NATASA; MORAIS MARTIN, MARIA DA GRACA; SANTOS, PEDRO PAIM; CARNEIRO, CAMILA DE GODOI; KERR, DANIEL SHIKANAI; AMARO, JR., EDSON; MCINTOSH, ANTHONY RANDAL; BUSATTO, GERALDO F.. Aging Effects on Whole-Brain Functional Connectivity in Adults Free of Cognitive and Psychiatric Disorders. CEREBRAL CORTEX, v. 26, n. 9, p. 3851-3865, SEP 2016. (10/17083-8, 12/50329-6, 11/00475-3, 12/11898-5)

FERREIRA, LUIZ KOBUTI; BUSATTO, GERALDO F.. Resting-state functional connectivity in normal brain aging. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 37, n. 3, p. 384-400, MAR 2013. (10/17083-8, 11/00475-3)