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Anatomical substrate for the neuroendocrine role of the incerto-hypothalamic area

Grant number: 11/09816-8
Support type:Regular Research Grants
Duration: October 01, 2011 - March 31, 2014
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal researcher:Luciane Valéria Sita
Grantee:Luciane Valéria Sita
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The incerto-hypothalamic area (IHy) is a diencephalic region poorly studied which is characterized by two non-colocalized neurochemical groups composed by the A13 dopaminergic group intermingled with predominantly GABAergic cells co-expressing melanin-concentrating hormone (MCH) and/or cocaine and amphetamine regulated transcript (CART). Functional studies suggest that IHy is involved in the neuroendocrine control of female reproduction in specific metabolic states mediated by MCH. In this way, our aim is to study the IHy connections in female rats related to neuroendocrine control of female reproduction using neuronal tracers and the IHy MCH expression in female rats during the estrous cycle. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BATTAGELLO, DANIELLA S.; DINIZ, GIOVANNE B.; CANDIDO, PAULO L.; DA SILVA, JOELCIMAR M.; DE OLIVEIRA, AMANDA R.; DA SILVA, KELLY R. TORRES; LOTFI, CLAUDIMARA F. P.; DE OLIVEIRA, JOSE A.; SITA, LUCIANE V.; CASATTI, CLAUDIO A.; LOVEJOY, DAVID A.; BITTENCOURT, JACKSON C. Anatomical Organization of Urocortin 3-Synthesizing Neurons and Immunoreactive Terminals in the Central Nervous System of Non-Human Primates [Sapajus spp.]. FRONTIERS IN NEUROANATOMY, v. 11, JUL 24 2017. Web of Science Citations: 2.
DOS SANTOS JUNIOR, EDMILSON D.; DA SILVA, ANDRE V.; DA SILVA, KELLY R. T.; HAEMMERLE, CARLOS A. S.; BATAGELLO, DANIELLA S.; DA SILVA, JOELCIMAR M.; LIMA, LEANDRO B.; DA SILVA, RENATA J.; DINIZ, GIOVANNE B.; SITA, LUCIANE V.; ELIAS, CAROL F.; BITTENCOURT, JACKSON C. The centrally projecting Edinger-Westphal nucleus-I: Efferents in the rat brain. Journal of Chemical Neuroanatomy, v. 68, p. 22-38, OCT 2015. Web of Science Citations: 13.
DUBIELA, FRANCISCO PAULINO; QUEIROZ, CLAUDIO MARCOS; MOREIRA, KARIN DI MONTEIRO; NOBREGA, JOSE N.; SITA, LUCIANE VALERIA; TUFIK, SERGIO; HIPOLIDE, DEBORA CRISTINA. AMPA receptors mediate passive avoidance deficits induced by sleep deprivation. Behavioural Brain Research, v. 257, p. 189-196, NOV 15 2013. Web of Science Citations: 9.

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