| Grant number: | 11/50256-6 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | November 01, 2011 |
| End date: | October 31, 2015 |
| Field of knowledge: | Biological Sciences - Immunology - Cellular Immunology |
| Principal Investigator: | José Daniel Lopes |
| Grantee: | José Daniel Lopes |
| Host Institution: | Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil |
| Pesquisadores principais: | Mario Mariano |
| Associated scholarship(s): | 13/22219-4 - The functions of Ikaros in differentiation of B-1 cells in phagocytes in vitro,
BP.IC 13/01049-3 - Study about the interaction between the invariant "Natural Killer" T limphocytes and B1 cells in immune response to Paracocciodioides brasiliensis, BP.DR |
Abstract
It has been previously demonstrated in our laboratory that the little studied subpopulation of B-1 cells has singular characteristics, including the ability to differentiate into either lymphoid or myeloid cells. This finding, among others, led us to demonstrate that these cells actively participate in inflammatory processes, even at sites distant from their natural habitat, as well as they present regulatory activities both, increasing or decreasing the immune response in dependence of different circumstances. For instance, they show important influence in the capacity of melanoma cells to metastasize, modify the course of chronic infectious diseases like paracoccidioidomycosis and interfere in various immunologic processes, including auto-immunity. This project intends to continue this line of investigation aiming to now demonstrate, on the one side, that these regulatory activities also influence the behavior of other immune response components, both cellular and molecular, hence modifying the Immune System as a whole. On the other side, their as yet unknown participation in other processes, such as physical exercise, visceral leishmaniosis or osteoclast formation will also be investigated, the latter opening a branch for the study of the emerging osteoimmunology. It is important to mention that the publication history of our group shows a very constant and productive line of investigation, whose scientific and technologic value can be verified by our results of the last years. Indeed, the present project will allow to explore new and neglected aspects of the Immune System and to contribute in the disclosure and production of molecules potentially useful for either diagnosis or treatment of different diseases. (AU)
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