Molecular and functional characterization of pelvic endometriosis stem cells

• Grant number: 11/14683-7
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2012
• End date: January 31, 2014
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Eduardo Schor
• Grantee: Eduardo Schor
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Adriana Luckow Invitti Nogueira ; Giovana Aparecida Gonçalves ; Hélio Sato ; Ismael Dale Cotrim Guerreiro da Silva ; Manoel João Batista Castello Girão

Abstract

Endometriosis is a cronic gynecological disorder defined as the presence of endometrial tissue within extra-uterine sites. It affects approximately 10 to 15% of all women of reproductive age and is responsible for a huge diminishing in their quality of life. The main symptoms are infertility and chronic pain. The proliferation of topic and ectopic endometrial tissue was demonstrated in several trials. According to this, and due to the recent identification of stem cells in the endometrial tissues, the study of the role of stem cells in the endometrial regeneration as well as in the mechanisms of the endometrium proliferative disequilibrium diseases like endometriosis has became of great interest. Following the newest finds in the field this project intends to isolate and characterize molecularly and functionally the stem cells of eutopic and ectopic endometrium from patients with endometriosis. The characterization will be carried out using several specific membrane markers, angiogenic potencial and cellular proliferative capacity determination; both with and without estrogen and progesterone exposition and by testing the paracrine effects generated in the co-cultive of normal endometrial derived stem cells and ectopic endometrioses implants stem cells. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

INVITTI, ADRIANA LUCKOW; SCHOR, EDUARDO; PARREIRA, RAFAEL MARTINS; KOPELMAN, ALEXANDER; KAMERGORODSKY, GIL; GONCALVES, GIOVANA APARECIDA; BATISTA CASTELLO GIRAO, MANOEL JOAO. Inflammatory cytokine profile of co-cultivated primary cells from the endometrium of women with and without endometriosis. MOLECULAR MEDICINE REPORTS, v. 18, n. 2, p. 1287-1296, AUG 2018. (11/14683-7)