Phylogeography of urban outbreaks of dengue virus in Jundiaí and Guarujá in the State of São Paulo

• Grant number: 10/19059-7
• Support Opportunities: Regular Research Grants
• Duration: November 01, 2011 - April 30, 2014
• Field of knowledge: Biological Sciences - Microbiology
• Principal Investigator: Paolo Marinho de Andrade Zanotto
• Grantee: Paolo Marinho de Andrade Zanotto
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Saulo Duarte Passos

Abstract

Both dengue viruses (DENV) types 1 and 2 were introduced in the State of Rio de Janeiro in 1986 and 1991, respectively. Since then, they have spread throughout Brazil and became endemic in most areas infested with Aedes aegypti. Dengue virus type 3 was introduced in 2001, also in the State of Rio de Janeiro, and dengue virus type 4 was documented in the State of Amazonas in 2008. Therefore, elucidating the temporal and spatial distributional pattern of DENV across time and space is critical to understand its epidemiology. However, the processes that shape the patterns of transmission of DENV in urban scales are not well understood. Particularly so is the impact of factors, such as movement of the human population and urbanization. More than 700 thousand cases of Dengue were reported in Brazil in 2010 with over 300 deaths. Up to March 2011 there were 55.083 cases reported in the State of Sao Paulo. Although the number of cases decreased by a 30% when compared with the total of cases reported by March 2010 (182.805), there was still a dramatic increase of 612%, when compared to the 8.996 cases reported in 2009, constituting an increasingly serious public health problem and highlighting the need to elucidate the pattern of distribution and spatial spread of viral strains. This project will obtain relevant information on the dynamics of DENV spread in urban settings in the State of Sao Paulo aiming to identify socioeconomic and demographic factors associated with the dynamic of viral dispersion, and combine phylogenetic, geographical and population information to reconstruct the history of the spread of the virus that may provide new perspectives to control strategies. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VILLABONA-ARENAS, CHRISTIAN JULIAN; DE OLIVEIRA, JESSICA LUANA; CAPRA, CARLA DE SOUSA; BALARINI, KARIME; LOUREIRO, MAURICIO; FONSECA, CELSO RICARDO THEOTO P.; PASSOS, SAULO DUARTE; DE ANDRADE ZANOTTO, PAOLO MARINHO. Detection of Four Dengue Serotypes Suggests Rise in Hyperendemicity in Urban Centers of Brazil. PLoS Neglected Tropical Diseases, v. 8, n. 2, FEB 2014. (11/17071-2, 10/19059-7)

VILLABONA-ARENAS, CHRISTIAN JULIAN; DE BRITO, ANDERSON FERNANDES; DE ANDRADE ZANOTTO, PAOLO MARINHO. Genomic mosaicism in two strains of dengue virus type 3. INFECTION GENETICS AND EVOLUTION, v. 18, p. 202-212, AUG 2013. (11/17071-2, 10/19059-7, 11/14537-0)

VILLABONA-ARENAS, CHRISTIAN JULIAN; DE ANDRADE ZANOTTO, PAOLO MARINHO. Worldwide Spread of Dengue Virus Type 1. PLoS One, v. 8, n. 5, MAY 13 2013. (11/17071-2, 10/19059-7)

VILLABONA-ARENAS, CHRISTIAN JULIAN; MONDINI, ADRIANO; BOSCH, IRENE; SCHIMITT, DIANE; CALZAVARA-SILVA, CARLOS E.; ZANOTTO, PAOLO M. DE A.; NOGUEIRA, MAURICIO L.. Dengue Virus Type 3 Adaptive Changes during Epidemics in Sao Jose de Rio Preto, Brazil, 2006-2007. PLoS One, v. 8, n. 5, MAY 7 2013. (11/17071-2, 12/11733-6, 10/19059-7, 11/10458-9)

VILLABONA-ARENAS, CHRISTIAN JULIAN; DE OLIVEIRA, JESSICA LUANA; DE SOUSA-CAPRA, CARLA; BALARINI, KARIME; THEOTO PEREIRA DA FONSECA, CELSO RICARDO; DE ANDRADE ZANOTTO, PAOLO MARINHO. Epidemiological dynamics of an urban Dengue 4 outbreak in Sao Paulo, Brazil. PeerJ, v. 4, APR 5 2016. (11/17071-2, 10/19059-7)