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Evaluation of a vaccine based on peptide-P10 and the therapeutic effect when administrate in combination with antifungal drugs in the fibrose experimental murine model induzed with Paracoccodioides brasiliensis conidia

Grant number: 11/17267-4
Support type:Regular Research Grants
Duration: January 01, 2012 - December 31, 2013
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Carlos Pelleschi Taborda
Grantee:Carlos Pelleschi Taborda
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Gil Benard

Abstract

Evaluate the effect of P10 peptide alone or in combination with antifungals in experimental model of pulmonary fibrosis using conidia of P. brasiliensis inoculated intranasally into BALB/c males, this effect will be determined by reducing the fungal burden, decreased pulmonary fibrosis and immune modulation at the treatment time. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BUENO, RENATA A.; THOMAZ, LUCIANA; MUNOZ, JULIAN E.; DA SILVA, CASSIA J.; NOSANCHUK, JOSHUA D.; PINTO, MARCIA R.; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P. Antibodies Against Glycolipids Enhance Antifungal Activity of Macrophages and Reduce Fungal Burden After Infection with Paracoccidioides brasiliensis. FRONTIERS IN MICROBIOLOGY, v. 7, FEB 3 2016. Web of Science Citations: 2.
MUNOZ, JULIAN E.; LUFT, VINICIUS D.; AMORIM, JULIANA; MAGALHES, ADRIANA; THOMAZ, LUCIANA; NOSANCHUK, JOSHUA D.; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P. Immunization with P10 Peptide Increases Specific Immunity and Protects Immunosuppressed BALB/c Mice Infected with Virulent Yeasts of Paracoccidioides brasiliensis. Mycopathologia, v. 178, n. 3-4, p. 177-188, OCT 2014. Web of Science Citations: 15.
THOMAZ, LUCIANA; NOSANCHUK, JOSHUA D.; ROSSI, DIEGO C. P.; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P. Monoclonal antibodies to heat shock protein 60 induce a protective immune response against experimental Paracoccidioides lutzii. Microbes and Infection, v. 16, n. 9, p. 788-795, SEP 2014. Web of Science Citations: 6.
FAINTUCH, BLUMA L.; OLIVEIRA, ERICA A.; MUNOZ, JULIAN E.; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P. Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties. Medical Mycology, v. 52, n. 5, p. 544-548, JUL 2014. Web of Science Citations: 0.
DE AMORIM, JULIANA; MAGALHAES, ADRIANA; MUNOZ, JULIAN ESTEBAN; RITTNER, GLAUCE M. G.; NOSANCHUK, JOSHUA D.; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P. DNA vaccine encoding peptide P10 against experimental paracoccidioidomycosis induces long-term protection in presence of regulatory T cells. Microbes and Infection, v. 15, n. 3, p. 181-191, MAR 2013. Web of Science Citations: 7.
MAYORGA, ORIANA; MUNOZ, JULIAN E.; LINCOPAN, NILTON; TEIXEIRA, ALINE F.; FERREIRA, LUIS C. S.; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P. The role of adjuvants in therapeutic protection against paracoccidioidomycosis after immunization with the P10 peptide. FRONTIERS IN MICROBIOLOGY, v. 3, 2012. Web of Science Citations: 16.

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