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Effects of intrauterine and puberal exposure to endocrine-disrupting chemicals on the old gerbils prostate

Grant number: 11/06335-9
Support type:Regular Research Grants
Duration: February 01, 2012 - January 31, 2014
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Sebastião Roberto Taboga
Grantee:Sebastião Roberto Taboga
Home Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil
Assoc. researchers:Fernanda Cristina Alcantara dos Santos ; Patricia Simone Leite Vilamaior

Abstract

The prostate is a gland that belongs exclusively to male mammals, can be found in female rodents and also in many women. Its development occurs under the influence of androgenic and estrogenic control a well regulated and precise, so that sensitive interference that may predispose the gland to develop diseases such as benign prostatic hyperplasia and cancer during life senile. Allied to this, a large number of studies have indicated that the predisposition to prostate disorders has its origin in the early stages of life, and the signaling pathways of ER and AR more sensitive to hormonal imbalance. These aspects are of great interest and concern, given that an increasing number of endocrine disrupting chemicals (EDCs) to which humans are exposed. The EDCs have the potential to compete for the androgen receptors present in prostate tissue and can activate cascades of events leading to expression of specific genes or even cause epigenetic changes in DNA. This interference, more harmful during critical periods of development may lead to imprint the prostate cells irreversibly. Therefore, to understand what are the mechanisms that may contribute to the predisposition to develop lesions of this gland throughout life is extremely important, so that these findings may help in the search for new treatments for prostate diseases. The objective is to evaluate the prostate gland of males and females senile Mongolian gerbil who were exposed to testosterone and ethinyl estradiol in intrauterine life and at puberty. For this, the prostates of these animals will be subjected to morphometric-stereological analysis, serological, immunohistochemical and ultrastructural. From the results obtained, possible mechanisms involved with the imprint of the prostate gland may be elucidated, making possible the understanding of these mechanisms with the development of prostate disease during senescence. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANTONIASSI, JULIA QUILLES; FOCHI, RICARDO ALEXANDRE; GOES, REJANE MAIRA; LEITE VILAMAIOR, PATRICIA SIMONE; TABOGA, SEBASTIAO ROBERTO. Corticosterone influences gerbil (Meriones unguiculatus) prostatic morphophysiology and alters its proliferation and apoptosis rates. International Journal of Experimental Pathology, v. 98, n. 3, p. 134-146, JUN 2017. Web of Science Citations: 1.
PEREZ, ANA P. S.; BIANCARDI, MANOEL F.; CAIRES, CASSIA R. S.; FALLEIROS, JR., LUIZ R.; GOES, REJANE M.; SANTOS, FERNANDA C. A.; TABOGA, SEBASTIAO R. Pubertal exposure to ethinylestradiol promotes different effects on the morphology of the prostate of the male and female gerbil during aging. ENVIRONMENTAL TOXICOLOGY, v. 32, n. 2, p. 477-489, FEB 2017. Web of Science Citations: 8.
PEREZ, ANA P. S.; BIANCARDI, MANOEL F.; CAIRES, CASSIA R. S.; FALLEIROS-JUNIOR, LUIZ R.; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; SANTOS, FERNANDA C. A.; TABOGA, SEBASTIAO R. Prenatal exposure to ethinylestradiol alters the morphologic patterns and increases the predisposition for prostatic lesions in male and female gerbils during ageing. International Journal of Experimental Pathology, v. 97, n. 1, p. 5-17, FEB 2016. Web of Science Citations: 5.
AZEVEDO SANCHES, BRUNO DOMINGOS; BIANCARDI, MANOEL FRANCISCO; ALCANTARA DOS SANTOS, FERNANDA CRISTINA; GOES, REJANE MAIRA; LEITE VILAMAIOR, PATRICIA SIMONE; TABOGA, SEBASTIAO ROBERTO. Budding Process During the Organogenesis of the Ventral Prostatic Lobe in Mongolian Gerbil. MICROSCOPY RESEARCH AND TECHNIQUE, v. 77, n. 6, p. 458-466, JUN 2014. Web of Science Citations: 17.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.