Evaluation of intrauterine oestrogenic exposure on the main epithelium-mesenchyme interaction pathways in the branching morphogenesis in the Mongolian Gerbil prostrate ventral lobe

• Grant number: 13/15939-0
• Support type: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): November 01, 2013
• Effective date (End): July 31, 2017
• Field of knowledge: Biological Sciences - Morphology - Histology
• Principal researcher: Sebastião Roberto Taboga
• Grantee: Bruno Domingos Azevedo Sanches
• Home Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil

Abstract

The branching morphogenesis is a typical developmental process of several organs not only in vertebrates, but also in arthropods. Recent studies indicate that the reactivation of this process in pathological conditions, especially the formation of tumors, which have been best studied for the lungs and prostate. Prostate is a reproductive accessory organ present in mammals, and the study of their formation process is particularly relevant to research on the correlations between development and tumor formation, since the study of this organ enables the possibility to evaluate the interaction between endocrine and paracrine signaling pathways, as well as such is subject to a high incidence of benign tumors with senescence. The Mongolian Gerbil (Meriones unguiculatus) is promising for this type of research, since the presence of prostate cancer in females is almost ubiquitous, as well as the occurrence of benign tumors in the gland is significantly elevated compared with that of other laboratory animals. This project aims to evaluate the influence of endocrine disrupters, particularly intrauterine exposure to high doses of estradiol on the main factors of autocrine and paracrine signaling that comprise the core of epithelial-mesenchymal interactions that occur during this stage of organogenesis of the ventral lobe prostate, specifically the branching process, as well as to investigate the presence of telocytes, interstitial cells that are related to the morphophysiological organization of stroma during the process of branching and the possible influence of estrogenization on such prostatic cells. This study is particularly relevant in view of the increase in industrialized societies of xenoestrogens exposure, in which mimic the effects of body estrogens, and which have disruptive effects on prostate organogenesis, which has been linked to an increased susceptibility to tumors of prostatic origin in both men and women. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MALDARINE, JULIANA S.; SANCHES, BRUNO D. A.; SANTOS, VITORIA A.; CABRAL, AGATA S.; LIMA, MARIA L. D.; BEDOLO, CAROLINA M.; CALMON, MARILIA F.; RAHAL, PAULA; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; TABOGA, SEBASTIAO R. Postnatal exposure to finasteride causes different effects on the prostate of male and female gerbils. Cell Biology International, v. 44, n. 6 MAR 2020. Web of Science Citations: 0.

MALDARINE, JULIANA S.; SANCHES, BRUNO D. A.; SANTOS, VITORIA A.; AMARO, GUSTAVO M.; CALMON, MARILIA F.; RAHAL, PAULA; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; TABOGA, SEBASTIAO R. Low-dose in utero exposure to finasteride promotes developmental changes in both male and female gerbil prostates. ENVIRONMENTAL TOXICOLOGY, v. 35, n. 1 AUG 2019. Web of Science Citations: 1.

MALDARINE, JULIANA S.; SANCHES, BRUNO D. A.; CABRAL, AGATA S.; LIMA, MARIA L. D.; GUERRA, LUIZ H. A.; BARALDI, CAROLINA M. B.; CALMON, MARTHA F.; RAHAL, PAULA; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; TABOGA, SEBASTIAO R. Prenatal exposure to finasteride promotes sex-specific changes in gerbil prostate development. REPRODUCTION FERTILITY AND DEVELOPMENT, v. 31, n. 11, p. 1719-1729, 2019. Web of Science Citations: 0.

ZANI, BRUNO C.; SANCHES, BRUNO D. A.; MALDARINE, JULIANA S.; BIANCARDI, MANOEL F.; SANTOS, FERNANDA C. A.; BARQUILHA, CAROLINE N.; ZUCAO, MARIELE I.; BARALDI, CAROLINA M. B.; FELISBINO, SERGIO L.; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; TABOGA, SEBASTIDO R. Telocytes role during the postnatal development of the Mongolian gerbil jejunum. Experimental and Molecular Pathology, v. 105, n. 1, p. 130-138, AUG 2018. Web of Science Citations: 3.

SANCHES, BRUNO D. A.; MALDARINE, JULIANA S.; BIANCARDI, MANOEL F.; SANTOS, FERNANDA C. A.; PINTO-FOCHI, MARIA E.; ANTONIASSI, JULIA Q.; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; TABOGA, SEBASTIAO R. Intrauterine exposure to oestradiol promotes sex-specific differential effects on the prostatic development of neonate gerbils. Cell Biology International, v. 41, n. 11, SI, p. 1184-1193, NOV 2017. Web of Science Citations: 2.

SANCHES, BRUNO D. A.; SANTOS, JULIANA M.; ZANI, BRUNO C.; BIANCARDI, MANOEL F.; SANTOS, FERNANDA C. A.; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; TABOGA, SEBASTIAO R. Intrauterine exposure to 17 beta-oestradiol (E2) impairs postnatal development in both female and male prostate in gerbil. REPRODUCTIVE TOXICOLOGY, v. 73, p. 30-40, OCT 2017. Web of Science Citations: 4.

SANCHES, BRUNO D. A.; MALDARINE, JULIANA S.; ZANI, BRUNO C.; BIANCARDI, MANOEL F.; SANTOS, FERNANDA C. A.; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; TABOGA, SEBASTIAO R. The Expression of the Androgen Receptor and Estrogen Receptor 1 is Related to Sex Dimorphism in the Gerbil Prostate Development. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology, v. 299, n. 8, p. 1130-1139, AUG 2016. Web of Science Citations: 2.

SANCHES, BRUNO D. A.; ZANI, BRUNO C.; MALDARINE, JULIANA S.; BIANCARDI, MANOEL F.; SANTOS, FERNANDA C. A.; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; TABOGA, SEBASTIAO R. Postnatal Development of Mongolian Gerbil Female Prostate: An Immunohistochemical and 3D Modeling Study. MICROSCOPY RESEARCH AND TECHNIQUE, v. 79, n. 5, p. 438-446, MAY 2016. Web of Science Citations: 5.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANCHES, Bruno Domingos Azevedo. Avaliação dos efeitos da exposição intrauterina ao 17ß-estradiol sobre o desenvolvimento prostático pós-natal no gerbilo da Mongólia. 2017. Doctoral Thesis - Universidade Estadual de Campinas, Instituto de Biologia.