| Grant number: | 11/17281-7 |
| Support Opportunities: | Regular Research Grants |
| Start date: | March 01, 2012 |
| End date: | February 28, 2014 |
| Field of knowledge: | Biological Sciences - Pharmacology - Neuropsychopharmacology |
| Principal Investigator: | Sâmia Regiane Lourenço Joca |
| Grantee: | Sâmia Regiane Lourenço Joca |
| Host Institution: | Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| City of the host institution: | Ribeirão Preto |
| Associated researchers: | Francisco Silveira Guimaraes |
Abstract
Recent studies indicate that epigenetic mechanisms migh be involved in the neurobiology of depression. For example, DNA methylation, which is associated with transcriptional repression, is increased by exposure to stress. Besides, high levels of methylation in specific gene loci were found in the brains of suicide victims. In addition, preliminary results of our research group showed that systemic administration of inhibitors of DNA methylation induces antidepressant-like effect in the forced swimming test. However, the molecular mechanisms and brain structures involved in these effects, as well as the pharmacological profile induced by these treatments, have not been investigated yet. Moreover, the effects induced by these treatments in animals exposed to other animal models predictive of antidepressant effects remains to be investigated.Therefore, this project aims to continue the investigation about the involvement of DNA methylation in the development of behavioral consequences induced by stress by studying the effects induced by other inhibitors of DNA methylation, as well as the molecular mechanisms involved in these effects. To do so, it will be tested the effects induced by acute and subchronic administration of nucleoside (5-aza-2-deoxiitidina) and non-nucleoside (RG-108) inhibitors of DNA methylation on the behavior of animals submitted to different models that involve presentation of stress (forced swimming, footshocks, restraint). In addition, we intend to evaluate the pattern of DNA methylation in candidate genes in structures involved in depression patophisyiology (hippocampus, prefrontal cortex and striatum) in response to treatment with DNA methylation inhibitors or with antidepressant drugs, in stressed and non stressed animals. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |