Effect of resistance training on blood pressure of elderly hypertensive patients: influence of angiotensin-converting enzyme polymorphism

• Grant number: 11/23830-3
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2012
• End date: March 31, 2014
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Ricardo Jose Gomes
• Grantee: Ricardo Jose Gomes
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
• Associated researchers: Patricia Chakur Brum

Abstract

Systemic arterial hypertension is a difficult disease to control, which in Brazil affects about 22 to 44% of the population. The aging increases susceptibility to hypertension, and also promotes muscle wasting, thereby increasing the risk of falls within the elderly. In contrast, the resistance exercise is recommended for increasing or maintaining muscle strength levels in the elderly. However, there is still no consensus in the literature about its effectiveness for hypertension treatment.There are several triggering factors of hypertension, such as sedentary lifestyle, smoking, alcohol consumption, overweight, genetic disorders, such as polymorphism of the angiotensin-converting enzyme (ACE), among others. Besides being a trigger factor of hypertension, ACE polymorphism may affect the response to treatment of hypertension. Therefore, the aim of this study is to verify the effect of resistance training on blood pressure in elderly hypertensive patients. Furthermore, to verify whether blood pressure of individuals are associated with different ACE genotypes.The hypothesis of this study is that elderly hypertensive patients subjected to resistance training will display lower blood pressure than untrained subjects and the magnitude of blood pressure fall will be related to ACE genotype, since hypertensive individuals with ACE D/D genotype will present smaller blood pressure fall after resistance training. To further evaluate the effect of resistance training on blood pressure of hypertensive subjects, different biochemical analysis will be evaluated before and after resistance training period to provide additional data to support the relationship between responsiveness to resistance training and ACE genotype. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MONTREZOL, FABIO T.; MARINHO, RODOLFO; DA MOTA, GLORIA DE F. A.; D'ALMEIDA, VANIA; DE OLIVEIRA, EDILAMAR M.; GOMES, RICARDO J.; MEDEIROS, ALESSANDRA. ACE GENE PLAYS A KEY ROLE IN REDUCING BLOOD PRESSURE IN THE HYPERINTENSIVE ELDERLY AFTER RESISTANCE TRAINING. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 33, n. 4, p. 1119-1129, APR 2019. (11/23830-3)