Leucine supplementation combined with resistance exercise improves the plasma lipid profile of dexamethasone-treated rats

• Grant number: 12/01289-1
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Start date: March 01, 2012
• End date: August 31, 2012
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Antonio Herbert Lancha Junior
• Grantee: Antonio Herbert Lancha Junior
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The impact of leucine supplementation and resistance exercise (RE) on plasma lipid profile was evaluated in adult rats treated with dexamethasone, an experimental model of dyslipidemia. Total cholesterol did not differ among groups. Furthermore, leucine supplementation did not promote improvement in the plasma total cholesterol and LDL-c of the animals. However, plasma TG and VLDL-c were significantly decreased and HDL-c increased after 7 days of leucine supplementation combined with RE. In conclusion, leucine supplementation combined with RE, but not isolated, improved the plasma lipid profile of dexamethasone-induced dyslipidemic rats. (AU)