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Bio-compatible luminescent nanoparticles: synthesis, characterization and applications

Grant number: 11/21551-0
Support type:Regular Research Grants
Duration: April 01, 2012 - March 31, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:José Maurício Almeida Caiut
Grantee:José Maurício Almeida Caiut
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Associating the luminescence from lanthanides ions, optimized by antenna effect imposed for specific ligands, with the nanoparticles physical-chemistry properties enables to obtain luminescent nanoprobes for bio-molecular identification. The nanoparticles provide a chemically and mechanically stable vehicle, which can protect the encapsulated rare earth ions from external perturbations (decreasing the luminescence quenching process) and its surface modification can become them biocompatible, a further request for biotechnology essays. The use of lanthanides ions allows applications where the luminescence measurement can be accomplished with temporary resolution, taking to a significant increase in the signal/noise ratio since europium and terbium complexes present excited states lifetimes of some milliseconds. This project can be divided in two parts. The first part involves academic studies and the second one, biotechnology applications. In all scope of this project, it is intended to develop, by the sol-gel methodology and spray pyrolysis process, the synthesis of luminescent nanoparticles with application in immunocytochemistry protocols. The particles, doped with lanthanide ions or its complexes, will be studied and the luminescence properties optimized by the coherent design of ligands and macro-structures. The biocompatibility and specificity of these particles requested for immunoassays will be achieved by the monoclonal antibody functionalization. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JUSTINO, LARISSA G.; NIGOGHOSSIAN, KARINA; CAPOTE, TICIANA S. O.; SCAREL-CAMINAGA, RAQUEL M.; RIBEIRO, SIDNEY J. L.; CAIUT, JOSE MAURICIO A. Multifunctional EuYVO4 nanoparticles coated with mesoporous silica. Journal of Luminescence, v. 179, p. 197-202, NOV 2016. Web of Science Citations: 1.
CAIUT, JOSE M. A.; MESSADDEQ, YOUNES; DEXPERT, HERVE; VERELST, MARC; RIBEIRO, SIDNEY J. L.; DEXPERT-GHYS, JEANNETTE. Luminescent Terbium Doped Aluminate Particles: Properties and Surface Modification with Asparagine. Journal of the Brazilian Chemical Society, v. 26, n. 12, p. 2536-2544, DEC 2015. Web of Science Citations: 0.
ALVES, CAROLINE CASSIA; DEMOUCRON, JULIEN; CAILLIER, BRUNO; GUILLOT, PHILIPPE; MAURICOT, ROBERT; DEXPERT-GHYS, JEANNETTE; ALMEIDA CAIUT, JOSE MAURICIO. Amino acid coupled to Pr3+ doped lanthanum orthophosphate (LaPO4) nanoparticles. Materials Letters, v. 137, p. 435-439, DEC 15 2014. Web of Science Citations: 4.

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