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Multifunctional Plataform based on luminescent rare earth fluoride and oxide for Theranostics

Grant number: 20/04157-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2022
Effective date (End): May 31, 2024
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal researcher:Rogéria Rocha Gonçalves
Grantee:Luiz Fernando dos Santos
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

This proposal aims at the preparation, characterization and application of nanoparticles with controlled morphology and dimensions for application in Theranostics. For such purposes, nanoparticles based on Y2O3, Gd2O3, Y2SiO5, TRF3, MTRF3 / MTR3F10 (M = alkali metal and TR = Rare Earth) doped with Eu3 +, Er3 +, Yb3 ++, Nd3 +, Ho3 + ions will be studied. Vibrational, structural and spectroscopic properties will be explored as well as tests involving biological applications. Homogeneous precipitation will be used as synthetic routes for the precursor particles of Y2O3 doped with TR3 + and coating with SiO2, through the sol-gel methodology to obtain Y2SiO5. The hydrothermal synthesis will be used for the preparation of the systems based on MTRF3 / MTR3F10. Luminescent properties will be explored in the visible range, upon excitation at UV-Vis or at the near infrared (NIR) region (up conversion), in addition to emission in the near infrared. Particle size control will be of sifnificant importance for the intended applications in this work. These syntheses and the morphological, structural and spectroscopic characterizations are the basis of the academic study. Analysis of up conversion processes will be carried out with the Er3 + / Yb 3+ co-doped systems, under excitation at 980 nm and 1550 nm (aiming at greater penetrability in biological systems). Analysis of the emission in the infrared region will be performed to the compounds doped with Nd3 +, Er3 + / Yb3 +, exploring biological transparency windows, for infrared biomaging, aiming at carrying out the applicability study as a biological optical marker, and simultaneously photoactivating the protoporphyrin IX to release singlet oxygen. The second part of this proposal, focuses on the biological applications of these nanoparticles. For this purpose, the glioblastomas multiform grade IV cell lines: T98G and U87MG and infantile glioblastoma: KNS42 will be cultivated for imaging and treatment of these neoplasms. Analysis of toxicity, cell viability and mechanisms of cell death. Study of the encapsulation of nanoparticles in nanocarriers will be performed for application as specific markers and also combined with protoprphyrin IX for photodynamic therapy for the treatment of neoplasms. For application validation in biological systems, spectroscopy analyzes will be performed on a single particle.

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