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Bone and metabolic phenotype in primary hyperparathyroidism before and after surgery treatment


Primary hyperparathyroidism (HPTP) is one of the major osteometabolic diseases affecting human beings due to its critical catabolic effect on bone tissue. Recently, several evidences show that bone tissue participates in other physiological activities, including participating in the regulation of energy metabolism. Osteocalcin, a peptide produced by osteoblasts appears to modulate the sensitivity and insulin secretion. This proposal aims at assessing the impact of changes in secretion of parathyroid hormone (PTH) on bone structure. We will evaluate quantitative and qualitative parameters. Patients will be assesed during active disease, catabolic phase, as well as six months after surgical resolution of PHPT (anabolic phase). In both periods, will be performed bone densitometry (lumbar spine, proximal femur, forearm and total body), panoramic mandibular and magnetic resonance imaging (imaging and spectroscopy) in the lumbar spine for evaluation of fat content in the vertebral body. Additionally, biochemical markers of bone remodeling, PTH, IGF-I, RANKL and osteoprotegerina will be evaluated in those above mentioned phases. Glucose metabolism will be determined by the measurement of serum glucose and insulin and the estimation of HOMAir index. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MAIRA L. MENDONÇA; SÉRGIO L. BATISTA; MARCELLO H. NOGUEIRA-BARBOSA; CARLOS E.G. SALMON; FRANCISCO J.A. DE PAULA. Primary Hyperparathyroidism: The Influence of Bone Marrow Adipose Tissue on Bone Loss and of Osteocalcin on Insulin Resistance. Clinics, v. 71, n. 8, p. 464-469, . (11/23952-1)

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